abstract background: keratoconus is a bilateral corneal disease, which one way to cure it is to transplant. the transplantation may be rejected by recipient's immune system, which leads to failure of the graft. this study aimed to analysis the factors affecting bilateral corneal graft rejection based on copula function. methods: a sample of bilateral graft rejection times was assessed. since co...

dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...

background acute rejection remains a major problem in renal transplantation and represents one of the most important causes of chronic allograft dysfunction and late graft loss. daclizumab is a genetically engineered human igg1 monoclonal antibody that binds specifically to the α chain of the interleukin-2 receptor, and may thus reduce the risk of rejection after renal transplantation. objectiv...

background: kidney transplantation is a preferred treatment for many patients with end-stage renal disease (esrd) and is far more profi table than hemodialysis. analyzing renal transplantation data can help to evaluate the eff ectiveness of transplantation interventions. the aim of this study was to determine the organ survival rate after kidney transplantation during a period of 10 years (marc...

purpose: to investigate the efficacy of topical cyclosporine a 2% in treating and preventing recurrent graft rejection episodes after penetrating keratoplasty (pkp) in patients with history of previous rejection episodes. methods: in this clinical trial, eligible pkp patients were randomly given topical cyclosporine a 2% or placebo in addition to a standard corticosteroid regimen for an episode...

introduction: due to its immunosuppressive properties, local graft irradiation (lgi) has been proposed as a second line therapy for treatment of acute kidney rejection. case presentation: in this case-series we report 6 patients with biopsy proven acute kidney allograft rejection refractory to conventional antirejection therapy who underwent lgi for treatment of acute rejection at our center. t...

introduction epithelial rejection typically begins in a linear pattern from the periphery of the graft and progresses centripetally. here in, we reported a patient with a new presentation of corneal epithelial graft rejection. case presentation a 23-year-old man presented with blurred vision two months after penetrating keratoplasty. conclusions slit lamp examination revealed sharply demarcated...

background and aim the most common complication of renal transplantation is allograft dysfunction, which in some cases leads to graft loss. the role of graft nephrectomy in the management of transplant failure is controversial. the procedure remains associated with a significant morbidity and also mortality. our main purpose was the comparison between clinical and pathological diagnosis of graf...

patients and methods we investigated the timing and frequency of acute rejection episodes related to long-term patient-graft survival in taleghani hospital between 1990 and 2011. recipients were divided into three groups as group-1 (no rejection), group-2 (early acute rejection [ear]: less than 3-months) and group-3 (late acute rejection [lar]: after 3 months of transplant). conclusions lar had...