We read with great interest the article ‘A case of emphysematous hepatitis with spontaneous pneumoperitoneum in a patient with hilar cholangiocarcinoma’ by Jung Ho Kim et al. The authors described fatal case of emphysematous hepatitis caused by C. perfringens , but did not mention the hemolysis or disseminated intravascular coagulopathy (DIC) during hospital course. Laboratory data on admission...

Staphylococcus aureus is a Gram-positive opportunistic pathogen that imposes heavy burden on society. What sets this apart the sheer spectrum of infections it can cause, which range from benign skin and soft tissue to lethal endocarditis bacteraemia. The ability S. cause gamut conferred by its arsenal virulence factors are under control Accessory Gene Regulator (Agr) system. However, large prop...

Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant-associated thrombotic microangiopathy (TA-TMA) after intestine-containing transplants remain scarce. We describe our centre’s experience these complications from 2007 to 2019. Ninety-six patients received 103 transplants. PLS occurred in 9 (9%) (median 12 days post-transplant); all due ABO antibodies. There we...

We report the case of an unexpected massive haemolysis occurred early after mitral valve repair. Potential underlying causes have been investigated, with review literature. After replacement, disappeared and patient recovered, returning to normal life 12 months.

The present study reports on the incidence and degree of intravascular haemolysis in 33 patients with Björk-Shiley tilting disc prosthesis and in 34 patients with Lillehei-Kaster pivoting disc valve prosthesis in the mitral position examined 12 to 24 months after the operation. Serum haptoglobin, serum lactate dehydrogenase, serum bilirubin, and haemoglobin estimations were performed. Significa...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a typical X-linked enzymopathy causing severe haemolytic anaemia in males, and mild to moderate anaemia in homozygous females. Haemolysis due to G6PD deficiency in patients with type 1 diabetes mellitus (T1DM) has been principally reported in males, but is uncommon. During the last 10 years 2 girls with an unknown incomplete G-6-PD deficien...

Hereditary spherocytosis is a genetically determined abnormality of red blood cells. It is likely that a defect of intracellular glycolysis results in the formation of spherical cells (spherocytes) which have a reduced life span and exhibit increased osmotic fragility in hypotonic saline solutions, increased susceptibility to mechanical trauma, and spontaneous lysis on incubation. Lysis is mark...

Since the first observation in Greece by Doxiadis, Fessas, and Valaes in 1960, it is now well established that a considerable proportion of full-term Greek newborns with severe jaundice (and/or anaemia) have G6PD deficiency. Similar cases have been described in other parts of the world (Freier, Mayer, Levene, and Abrahamov, 1965). G6PD deficiency and increased haemolysis are obviously cause and...

BACKGROUND It is unclear why haemolysis may somewhat persist in patients with cold autoimmune haemolytic anaemia (cAIHA) at 37 °C (core temperature). METHODS Seven patients with cAIHA were included in this study. Serological testing was performed using standard techniques. Bound autoantibodies (aab) on patients' RBCs were analysed by the direct antiglobulin test (DAT), dual antiglobulin test ...