in psychopathology, which worsened after a three-day washout period and became similar to that seen before metoclopramide treatment. The patient was then treated with the classical neuroleptic haloperidol. At a dose of 45 mg/day the same extrapyramidal syndrome re-emerged and was completely responsive to trihexyphenidyl 2 mg by mouth three times daily. After haloperidol dosage was increased to ...

Objective(s) Psychotropic medications produce their effects, in part, through increasing neurotrophin levels in the brain. Since studies concerning nerve growth factor (NGF) analysis have been limited in scope, in the current experiments we investigated the effects of diverse psychotropic agents on NGF protein levels in various brain regions of rat. Materials and Methods Male Wistar rats rec...

A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration ...

Abst rac t Objective: The purpose of this study was to evaluate the rehospitalization rates of patients discharged from the Institute of Psychiatry of the Clinical Hospital of the Medical School of the Universidade de São Paulo while being treated with haloperidol, risperidone or clozapine. Method: This is a naturalistic study designed to monitor rehospitalization rates for patients discharged ...

Paranoid schizophrenia with long-term course is a challenge for the clinical and therapeutic research, particularly because chronic course is difficult to identify due to the high rate of mortality in this category of patients. The therapeutic stability on an antipsychotic molecule (haloperidol) is indeed an exception, since the current trend in the case of unfavorable course is based on therap...

Recent evidence has suggested that atypical antipsychotic drugs regulate synaptic plasticity. We investigated whether some atypical antipsychotic drugs (olanzapine, aripiprazole, quetiapine, and ziprasidone) altered the expression of synapse-associated proteins in rat hippocampal neuronal cultures under toxic conditions induced by B27 deprivation. A typical antipsychotic, haloperidol, was used ...

Purpose: To identify the prevalence of potential drug-drug interactions (pDDIs) in a psychiatric ward, their levels and association with risk factors. Methods: This study was conducted in the psychiatric ward of Ayub Teaching Hospital, Abbottabad, Pakistan. Medical records of 415 patients were retrospectively reviewed for pDDIs using Micromedex Drug-Reax software. Logistic regression was applie...

Background: The nursing staff at the authors’ hospital are frequently called upon to administer medications by intramuscular injection during psychiatric emergencies. Many of these medications are considered incompatible when mixed together, and up to 3 separate injections may be required for a single patient. The need for multiple injections increases the risk of needle-stick injury in these s...