Histone deacetylases are ubiquitous and highly conserved enzymes across all kingdoms of life. Plant HDAs regulate gene expression control development stress response, but little is known about their structure biochemistry. Structural biochemical studies have revealed diverse functions in mammals beyond deacetylation histones chromatin remodeling. A revised holistic phylogenetic analysis highlig...

Epigenetics has been recognised to play vital roles in many plant developmental processes, including floral initiation through the epigenetic regulation of gene expression. The histone modifying proteins that mediate these modifications involve the SET domain-containing histone methyltransferases, JmjC domain-containing demethylase, acetylases and deacetylases. In addition, RNA interference (RN...

Valproic acid/sodium valproate (VPA), a drug primarily used for treatment of seizure disorders, is recognized as an efficient epigenetic agent, inducing inhibition histone deacetylases, promoting changes in the methylation status DNA and histones, affecting chromatin structure. In addition to these effects, molecular affinity VPA H1 has been proposed based on thermal denaturation, fluorescence ...