spinal cord injury (sci), a common result of car accidents, high-altitude falls and crashes, and other violent injuries is increasing yearly. histone deacetylases (hdac) inhibitors including depakine the main characteristics of the use of anti-inflammatory. the purpose of this investigation is to evaluate the effect of depakine intervention on the acute sci at the chronic phase using functional...

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

Histone deacetylases (HDACs) and histone acetyltransferases (HATs) maintain the balance of histone acetylation, and play important role in chromosome modification and gene expression. Histone deacetylases have been identified to modify acetylation of proteins other than histones and inhibit gene expression. Here we summarize the functions of histone deacetylases in glycometabolism including the...

Acetylation of lysines is a prominent form of modification in mammalian proteins. Deacetylation of proteins is catalyzed by histone deacetylases, traditionally named after their role in histone deacetylation, transcriptional modulation, and epigenetic regulation. Despite the link between histone deacetylases and chromatin structure, some of the histone deacetylases reside in various compartment...

Abstract Histone deacetylases are important epigenetic regulators that have been reported to play essential roles in cancer stem cell functions and promising therapeutic targets many cancers including glioblastoma. However, the functionally relevant of specific histone deacetylases, maintenance key self-renewal growth characteristics brain tumour (BTSC) sub-populations glioblastoma, remain be f...

This “Minireview and Perspective” article describes histone deacetylases (HDACs), as promising specific molecular targets to treat a variety of disease states by downregulating the expression associated proteins with use new generation bioengineered compounds called protein targeting chimeras (PROTACs). We present classification HDACs, discuss their functions key epigenetic regulators gene expr...