BACKGROUND We investigated the hypothesis that an ultrasound transducer positioned within an angioplasty balloon could be used to perform quantitative assessment of arterial dimensions before and after percutaneous transluminal angioplasty (PTA) and to identify certain mechanical alterations consequent to PTA, including vascular wall recoil and the initiation of plaque fractures. METHODS AND ...

Gene amplification is frequently found in human glioblastoma but the mechanisms driving amplifications remain to be elucidated. Hypoxia as hallmark of glioblastoma is known to be involved in the induction of fragile sites that are central to gene amplification. We analyzed the potential of hypoxia (pO2 0%) and mini hypoxia (pO2 5%) to induce fragile sites within a homogeneously staining region ...

Cytogenetic abnormalities associated with the acquisition of doxorubicin (DOX) resistance (DOXR) were examined in two cell lines (HT1080 fibrosarcoma and LoVo colon adenocarcinoma) which were selected in the presence of increasing concentrations of DOX over a 2-year period. Karyotypes of both tumor lines were initially near-diploid although they differed significantly in their intrinsic sensiti...

Multiple myeloma is a disease with a high initial chemotherapeutic response but virtually no cures due to emergence of drug resistance. A doxorubicin-resistant human myeloma cell line (8226/Dox) has been selected from the myeloma cell line RPMI8226 by continuously exposing cells to gradually increasing doses of doxorubicin. The resistant phenotype has been retained for over 2 months despite gro...

The mammary carcinoma cell line MFM-223 is characterized by high androgen and low estrogen and progesterone receptor levels. With the dextran charcoal method, androgen binding was determined at 160 fmol/mg protein corresponding to approximately 100,000 binding sites per cell in whole cell binding assays. The estrogen and progesterone receptor contents were between 8 and 18 fmol/mg protein. The ...

A graph is called almost self-complementary if it is isomorphic to the graph obtained from its complement by removing a 1-factor. In this paper, we study a special class of vertex-transitive almost self-complementary graphs called homogeneously almost selfcomplementary. These graphs occur as factors of symmetric index-2 homogeneous factorizations of the “cocktail party graphs” K2n − nK2. We con...

We study the linkage classes of homogeneous ideals in polynomial rings. An ideal is said to be homogeneously licci if it can be linked to a complete intersection using only homogeneous regular sequences at each step. We ask a natural question: if I is homogeneously licci, then can it be linked to a complete intersection by linking using regular sequences of forms of smallest possible degree at ...

An interleaver is a critical component for the channel coding performance of turbo codes. Algebraic constructions are of particular interest because they admit analytical designs and simple, practical hardware implementation. Also, the recently proposed quadratic permutation polynomial (QPP) based interleavers by Sun and Takeshita (IEEE Trans. Inf. Theory, Jan. 2005) provide excellent performan...

This paper gives a new approach to decoding Hermite codes using the key equation, avoiding the use of majority voting. Our approach corrects up to (dmin − 1)/2 errors, and works up to some extent also beyond. We present an efficient implementation of our algorithm based on a Sugiyamatype iterative procedure for computing solutions of a key equation.