The presence of adherens junctions and the associated protein β-catenin are requirements for development glucose-stimulated insulin secretion (GSIS) in β-cells. Evidence indicates that modulation function response to changes glucose levels can modulate from β-cells but role phosphorylation this process has not been established. We find a Ser552Ala version attenuates indicating functional Ser552...

Scoliosis is a three-dimensional structural deformity of the spine; more than 80% scoliosis has no specific pathogenesis but understood to be closely related genetic, hormonal, and environmental factors. In recent years, epigenetic alterations observed in have been analyzed numerous studies determine progression this condition, however, there currently comprehensive review factors date. We sear...

Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences ...

A number of hypotheses have been implicated in the etiology of benign prostatic hyperplasia (BPH). The most important theories are: (1) an alteration of the androgen metabolism in BPH if compared to the normal prostate (NPR) leading to an accumulation of the biologically highly active androgen 5αdihydrotestosterone (DHT) predominantly in the stroma; (2) a change in the androgen-estrogen ratio i...

An in vivo screening assay using intact adult male rats has been evaluated for its ability to detect six antiandrogenic compounds via oral administration. The test compounds included cyproterone acetate (CPA), flutamide (FLUT), p,p'-DDE (DDE), di-n-butyl phthalate (DBP), linuron (LIN), and vinclozolin (VCZ). Two of the test compounds (DDE and FLUT) have been previously evaluated in the 15-day i...

BACKGROUND AND OBJECTIVE: Ketogenic diet (KGD) is a low-carbohydrate, high-fat and average protein dietary formulation, which has been reported with the ability to ameliorate several metabolic diseases, especially those under the direct influence of hormonal disruptions. Monosodium glutamate (MSG) had been found to induce uterine fibroids in laboratory animals through alterations to hormones, l...

different contraceptive methods are used by breastfeeding mothers. in general, these methods are classified into two major groups, hormonal and non-hormonal. a number of studies have shown that combined oral contraceptive pills may adversely affect the quality and the quantity of human milk. in other studies it has been shown that estrogen and progesterone seem to reduce the risk of cardiac and...

Anorexia nervosa is a serious psychiatric disorder accompanied by high morbidity and mortality. It is characterized by emaciation due to self-starvation and displays a unique hormonal profile. Alterations in gonadal axis, growth hormone resistance with low insulin-like growth factor I levels, hypercortisolemia and low triiodothyronine levels are almost universally present and constitute an adap...