Recently, detection of human papillomavirus (HPV)mRNA expression was made possible by in situ hybridization. We described a patient with cervical intraepithelial neoplasia (CIN) 3, showing a distinctive and rare form of co-infection with HPV type 16 and 18. HPV-16 was detected in high grade squamous intraepithelial neoplastic lesion (CIN 3) and HPV-18 was in low grade lesion just adjacent to th...

The E6 and E7 genes of HPV-16 or HPV-18 both are necessary for effective immortalization of primary human genital keratinocytes. To analyse the individual role of E6 and E7 genes in dysregulating cell growth, we cloned the HPV-16 E6, E7 and E6/E7 genes into retroviruses. Primary human keratinocytes (PHK) were then infected with these retroviruses and selected in differentiation-inducing medium ...

In 2006, an adjuvant vaccine against 4 human papillomavirus (HPV) types was licensed. By 2012, 45 countries had introduced HPV vaccination. HPV encompasses a group of more than 100 viruses, of which at least 13 are high-risk types, responsible for cervical and other anogenital cancers. There are currently 2 vaccines that prevent HPV 16 and 18 infection (known to cause 70% of cervical cancers) a...

Background: The pathogenesis of endometriosis is still debatable, and many studies reported a predisposition to infectious immunological factors. In this study, we aimed evaluate the human papillomavirus (HPV) positivity in pain-related symptoms infertility. Methods: cross-sectional 410 patients were enrolled study. HPV-positive (n = 202) HPV-negative 208) compared with symptoms, infertility, e...