background: recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. we aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. methods: in vitro susceptibility to samples of 10 random human platelet concentrates was determine...

Platelets are anucleate blood cells, which play an important part in haemostasis and maintenance of the integrity of blood-vessel endothelium. Interaction of platelet glycoproteins (GPs) with extracellular matrix proteins is critical to this function. The original impetus for investigating the alloantigens found on the GPs of the platelet membrane came from clinical observations of pathological...

BACKGROUND AND PURPOSE Multiple platelet transfusions may induce alloimmunization. Platelet alloimmunization involves human leukocyte antigen (HLA) antibodies and platelet-specific antibodies, which recognize platelet glycoproteins. No data are available about the frequency and characteristics of platelet-specific antibodies in patients who have received multiple platelet transfusions in Taiwan...

Platelet membrane glycoprotein Iba (GPIba) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIba. The relevance of these polymorphisms to thrombotic disease was investigated by genotypic identification in three case-control studies: 104 case p...

Background: Recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. We aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. Methods: In vitro susceptibility to samples of 10 random human platelet concentrates was determin...

In a case of chronic thrombocytopenic purpura, significant lymphocyte transformation could be induced with autologous platelets as a stimulant. The reaction was not due to serum factors since it occurred when culture medium was supplemented either with autologous or pooled human serum. Controls excluded nonspecific lymphocyte transformation. Modulation of normal platelet antigens by viral or ch...

Neisseria adhesin A (NadA) is present on the meningococcal surface and contributes to adhesion to and invasion of human cells. NadA is also one of three recombinant antigens in the recently-approved Bexsero vaccine, which protects against serogroup B meningococcus. The amount of NadA on the bacterial surface is of direct relevance in the constant battle of host-pathogen interactions: it influen...