Hutchinson-Gilford Progeria Syndrome (HGPS) (Phenotype MIM number 176670) is an autosomal-dominant genetic disorder that leads to accelerated aging and often premature death caused by cardiovascular complications. HGPS origined abnormal Lamin A formation, directly a mutation in exon 11 of the LMNA gene. This syndrome characterized presence aging-associated symptoms, including lack subcutaneous ...

In an editorial titled “We Need to Talk About Corruption in Health Systems” the authors Hutchinson, Balabanova, and McKee hope to encourage a wider conversation about corruption in the health sector. Such conversations are difficult to hold for at least five reasons; it is hard to define corruption; corruption may allow some fragile health systems to subsist, shifting blame – are those involved...

Hutchinson-Gilford Progeria (acute premature aging) is caused by a de novo point mutation in the lamin A gene. Recently, this has been accurately corrected base editing patient cell lines and mouse model, resulting nearly complete reversal to normal phenotype. This success opens perspective for clinical applications other diseases.

Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease. We show here that cellular aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by a period of hyperproliferation and terminates with a large increase in the rate of apoptos...

1818. Immunogenicity of Inactivated Varicella Zoster Vaccine (ZVIN) in Autologous Hematopoietic Stem Cell Transplant (auto-HSCT) Recipients Michael Boeckh, MD, FIDSA; Ann Arvin, MD, FIDSA, FPIDS; Kathleen Mullane, DO, FIDSA; Drew J. Winston, MD; Janice (Wes) Brown, MD; Steven Pergam, MD, MPH, FIDSA; Kimberly Hurtado, BS; Lei Pang, PhD; Ingi Lee, MD, MSCE; Zoran Popmihajlov, MD, MS and on behalf...

approaches to biological diversity; Hutchinson contrasted the ecological theatre with the evolutionary play. Thus Darwin sought to understand the origins of diversity among individuals and species, while ecologists such as Elton and Hutchinson have tended to concentrate on the maintenance of diversity at the species level and above. As Levin repeatedly informs us, this division of processes is ...

Abstract This article advances the reconstruction of ‘literary culture nonconformity’ by examining activities memorializing and collecting within congregation with which Lucy Hutchinson was associated in 1670s. congregation, led John Owen, retained a distinctive political culture. In spring 1673, its female adherents included widow daughter former members Council State, while 15 men membership ...

Let [Formula: see text] be a compact metric space and let continuous. We study text]-algebra generated by all multiplication operators continuous functions on composition operator induced certain space. system of proper contractions text]. Suppose that are inverse branches is self-similar. consider the Hutchinson measure Then we show C[Formula: isomorphic to associated with under some conditions.