SAMMENDRAGBakgrunn: Legemiddelbruk i den norske befolkningen er økende. Kunnskap om omfang, hvem brukerne og bruksmønster en forutsetning for optimalisering av legemiddelbruk alle grupper befolkningen. Samtidig finnes det ingen oppdaterte studier som viser bruk forskrevne legemidler blant innsatte Norge. Hensikten med denne studien derfor å beskrive psykofarmaka fengsel før under soning, samt u...

Psychotropic medications metabolized by cytochromes P450 (CYP) 2D6 are reviewed, and the possible relevance of this metabolism to drug-drug interactions is discussed. CYP2D6 is a member of the cytochrome P450 super family and it plays a primary role in the metabolism of more than 70 substrate medications, belonging to classes such as antidepressants, antipsychotics, mood stabilizers, antiarthem...

Benzodiazepines (BZDs) are widely available drugs. In the adult population, the prevalence of daily use of anxiolytic drugs is 4%, and the prevalence of daily use of hypnotics is 1.7%, according to a Spanish survey conducted in 2011 [1]. This is due to their anxiolytic, sedative, and hypnotic properties, and also because they have shown to have a broad-spectrum activity, a rapid onset of action...

Fibromyalgia (FM) is a common syndrome characterised by widespread pain and at least 11/18 painful tender points that requires multimodal pharmacological treatment also combined with non-pharmacological therapy. Various drugs currently are available to control the complex and different symptoms reported by patients. Only three drugs (duloxetine, milnacipram, pregabalin) are approved by the Amer...

Cortical evoked response audiometry is adequate for approximating hearing threshold levels with frequency specificity when the psychoacoustic responses lack reliability and reproducibility (compensation claim). It is well-known that control of wakefulness is essential for the reliability of slow vertex responses (SVR). Therefore, sedative, hypnotic, and neuroleptic drugs are supposed to have po...

Background. Nonmedical prescription drug use (NMPDU) is an increasing problem, insufficiently studied among people in opioid maintenance treatment (OMT). This study investigates the prevalence of and factors associated with NMPDU for drug classes insufficiently described in opioid-dependent populations, including antihistaminergic anxiolytics and central stimulants. Methods. Study participants ...

AIM To determine drug prescription and proportion of off-label dispensing in the Swedish paediatric outpatient population. METHODS All dispensed outpatient prescriptions to children aged 0 < 18 years as well as the proportion of off-label drug use during 2007 were analysed using data from the Swedish Prescribed Drug Register. RESULTS In total, 2.19 million drug prescriptions of 898 differen...

Exposure to acute psychological or physical stress increases core body temperature (stress-induced hyperthermia, SIH) which is part of the autonomic stress response. SIH is used as a putative rodent anxiety paradigm in which anxiolytic drugs reduce the SIH response. The predictive validity of the SIH paradigm has proven to be good, making it suitable to detect the putative anxiolytic properties...