CLINICAL SUMMARY Mediastinal enlargement and a solitary pulmonary nodule were detected on a 68-year-old male patient’s chest radiograph during routine annual examination. Computed tomography and magnetic resonance imaging revealed a lobulated, solid, and well-demarcated right paratracheal mass 6 3 4 3 4 cm in dimension (Figure 1). The solitary, heterogeneous parenchymal mass located in the righ...

 Parathyroid adenoma involving a single parathyroid gland is the underlying cause of 80-85% of primary hyperparathyroidism (PHPT). Skeletal system is significantly affected by PHPT. Brown tumors are known to have affinity for 99mTc-MIBI. We report a rare case of PHPT presenting with diffuse bony pain, high calcium level and significantly elevated alkaline phosphatase level. 99m<...

Aim: To compare the ARFI elastographic and scintigraphic quantitative data obtained from thyroid gland to evaluate diagnostic value of measurements in autoimmune diseases.&#x0D; Material Method: In study a total 61 patients (41 women, 20 men) including 24 Graves’ disease, 15 Hashimoto disease 22 control subjects. The mean age was 33.9±10.9 years. Patients with nodules were not included study. T...

Monte Carlo (MC) modelling is widely used in the field of single photon emission computed tomography (SPECT) as it is a reliable technique to simulate very high quality scans. This technique provides very accurate modelling of the radiation transport and particle interactions in a heterogeneous medium. Various MC codes exist for nuclear medicine imaging simulations. Recently, new strategies exp...

A 64-year-old man presented with clinical unilateral thyroiditis after chronic left neck trauma from his car seat belt. Thyroid function tests were normal. The initial thyroid Tc-99m pertechnetate scan demonstrated decreased uptake in the entire left lobe of the thyroid. The follow-up scan 1 month later showed a more normal uptake in the left lobe. This patient's clinical course, laboratory val...

BACKGROUND Circadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-wide transcriptional regulation and responses of potential biomarkers and signature genes in normal mouse tissues at 24 h after i.v. administration of (131)I. METHODS Female B...

UNLABELLED The aim of this study was to evaluate 3 new (99m)Tc-labeled minigastrin analogs modified with open chain tetraamines at the N-terminus for their suitability in the CCK-2/gastrin-R-targeted imaging of tumors (CCK-2/gastrin-R = cholecystokinin subtype 2/gastrin receptor). METHODS The [(D)Glu(1)]minigastrin sequence was assembled on the solid support and the respective tetraamine prec...

OBJECTIVE The current study aimed to determine the efficacy of radioiodine-131 ((131)I) ablation therapy with thyroid hormone replacement one day before (131)I administration in patients with well-differentiated thyroid cancer (DTC). METHODS This retrospective study included 29 patients who underwent (131)I therapies twice for DTC during 6-12 months. Since all the patients obviously had resid...

The aim of the present study was to investigate in detail the variation of the intrinsic spatial resolution across the useful field of view (UFOV) of gamma-cameras and to explore whether this variation could lead to observable effects in clinical images. Two gamma-cameras were used, without their collimators, to acquire 560 (99m)Tc point source images at different points across their UFOVs, in ...