OBJECTIVE To assess strategies for advice on analgesia and steam inhalation for respiratory tract infections. DESIGN Open pragmatic parallel group factorial randomised controlled trial. SETTING Primary care in United Kingdom. PARTICIPANTS Patients aged ≥ 3 with acute respiratory tract infections. INTERVENTION 889 patients were randomised with computer generated random numbers in pre-pre...

OBJECTIVE To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home. DESIGN Individually randomised, blinded, three arm trial. SETTING Primary care and households in England. PARTICIPANTS Children aged between 6 months and 6 years wi...

Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over the counter analgesic and antipyretic for adults and children. Ibuprofen has been rated as the safest conventional NSAID by spontaneous adverse drug reaction reporting systems in the UK. This article summarizes the main pharmacological effects, therapeutical applications and advers...

Objective: Craving for substance abuse is a usual and complicated problem in patients, with opioid addiction who are in opioid detoxifying process. Craving has been added as one of the diagnostic criteria of substance use disorders in DSM-5. The present trial aimed at comparing the effects of celecoxib versus ibuprofen in reducing pain and decreasing the desire to use opiates in patients underg...

Glucosamine (2-amino-2-deoxy-d-glucose) and glucosamine-containing products have been reported to have efficacy in the treatment of various musculoskeletal disorders. Glucosamine's efficacy, including reduction of pain, is attributed to disease-modifying properties, specifically to cartilage-rebuilding associated with modulation of interleukin-1-induced activation of chondrocytes and to inhibit...

The aim of the investigation is to validate the potential of SAS crystallization process to resolve racemic ibuprofen. The resolution is performed via diastereomic salt formation and subsequent salt precipitation in a supercritical CO2 environment. Firstly, the operating conditions, using (S)-α-methylbenzylamine as resolving agent, were optimized. Secondly, the measurement of the binary phase d...

We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, i...

ibuprofen was positive in a residual lesion, while patch test with the same drug was negative in upper back. We were curious to know if our patient was sensitised to the rest of the propionic acid group, but due to the small area affected skin, we could not test these additional drugs. Therefore all propionic acid group drugs were forbidden. The patient tolerated acetylsalicylic acid, and then ...