نتایج جستجو برای: induced pluripotent stem cells
تعداد نتایج: 2212149 فیلتر نتایج به سال:
Ex vivo production of human red blood cells from hematopoietic stem cells: what is the future in transfusion? Hematopoietic colony-forming cells derived from human embryonic stem cells. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. et al. Induction of pluripotent stem cells from adult human fibrob-lasts by defined factors. Tian S, et ...
The Mediator complex has recently been shown to be a key player in the maintenance of embryonic and induced pluripotent stem cells. However, the in vivo consequences of loss of many Mediator subunits are unknown. We identified med14 as the gene affected in the zebrafish logelei (log) mutant, which displayed a morphological arrest by 2 days of development. Surprisingly, microarray analysis showe...
Since the embryonic stem cells have knocked the doorsteps, they have proved themselves in the field of science, research, and medicines, but the hovered restrictions confine their application in human welfare. Alternate approaches used to reprogram the cells to the pluripotent state were not up to par, but the innovation of induced pluripotent stem cells (iPSCs) paved a new hope for the researc...
Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from fibroblasts of 3 different normal individuals using a standardized approach tha...
The path to induced pluripotency Discovery of a pan-species pluripotency network Animal iPSCs and disease modelling Issues with large animal iPSCs Conclusions The derivation of human embryonic stem cells and subsequently human induced pluripotent stem cells (iPSCs) has energized regenerative medicine research and enabled seemingly limitless applications. Although small animal models, such as mo...
Human-Induced Pluripotent Stem Cells The ability to reprogram adult mammalian somatic cells to a pluripotent state has proven to be a paradigm shifting discovery. In 2007, this reprogramming technology was translated to the engineering of human-induced pluripotent stem cells (hiPSCs) using skin fibroblasts by both the Yamanaka (transduction of c-Myc, Oct3/4, SOX2, and Klf4) and Thomson (transdu...
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Klf4), represents a major breakthrough in stem cell research. The reprogrammed cells, known as induced pluripotent stem (iPS) cells, possess many of the properties of ES cells, and represent o...
Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio et al (2016) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proli...
By injecting induced pluripotent stem cells (iPSCs) into tetraploid blastocysts to generate live pups, two groups in China demonstrated that the injected cells are as pluripotent as embryonic stem cells, i.e. capable of giving rise to every cell in the newborn mice. This achievement validates iPS technology for regenerative medicine.
Induced pluripotent stem cells (iPSCs) generated by ectopic expression of four transcription factors have great promises for regenerative medicine in humans. Since the initial report of iPSCs by viral transfection, ample efforts have been made in the generation of iPSCs through nonviral approaches. Small molecules offer the advantages of low cost without genomic modification and have been used ...
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