Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes 'healthy brain aging' very important. Studies suggest that caloric restriction (CR) non-genetic intervention reliably extends life- and healthspan. Here, we review the CR literature related to both subject of aging alterations in cell cycle machinery, espe...

Meta-analysis is a standard statistical method used to combine the conclusions of individual studies that are related and the results of single study alone can not answered to deal with issues. The data are summarized by one or more outcome measure estimates along with their standard errors. The multivariate model and the variations between studies are not considered in most articles. Here we d...

This paper sheds some light on the problems associated with random effects gravity approaches. Arguments for the superiority of a fixed effects model are given both along intuitive and econometric lines based on a Hausman test.  2000 Elsevier Science S.A. All rights reserved.

This paper uses data drawn from the English Football League to model separate hazard rates for club managers for the 2001/2, 2002/3 and 2003/4 seasons. On average over the three seasons, approximately one-third of managers involuntarily exited employment status with their club. We model the hazard using a standard logistic model exploiting information on the spell at risk rather than the indivi...

Integrative behavioural couple therapy (IBCT) Traditional TBCT relied for its effectiveness on the ability of couples to accommodate and collaborate with each other. Aware that many couples could not do this, and that conflict could have positive as well as negative effects, Jacobson and Christensen developed the model to incorporate ‘acceptance’ as a central focus for couples with irreconcilab...

maternal effects mediate impacts of a warming ocean Lisa N. S. Shama*, Anneli Strobel, Felix C. Mark and K. Mathias Wegner Coastal Ecology Section, Alfred-Wegener-Institut Helmholtz-Zentrum f€ ur Polarund Meeresforschung, Wadden Sea Station Sylt, Wadden Hafenstrasse 43, 25992 List, Germany; and Integrative Ecophysiology Section, Alfred-WegenerInstitut Helmholtz-Zentrum f€ ur Polarund Meeresfors...