A case of chronic urticaria in a child 6 years old is described. The strong skin reactivity upon intradermal injection of autologous serum suggested an autoreactive pathogenesis; however, patient's serum was unable to induce histamine release from basophils in-vitro, indicating the presence of a histamine-releasing factor specific for mast cells, and possibly other than an anti-FcepsilonRI or a...

The production of a systemic inflammatory response to intradermal monosodium urate crystal injection is described. A transient, self-limiting local response is associated with a systemic response detectable by a rise in the white cell count and serum amyloid A protein. The white cell change parallels the evolution of the local response, whereas the serum amyloid A response lags behind the local...

Rabbits were sensitized by a single intravenous injection of horse serum 6 days prior to the experiments. In these rabbits there appeared hemorrhagic and necrotic reactions in sites of intradermal tests with horse serum when the tests were preceded by 1 hour, or followed 18 to 24 hours later by an intravenous injection of potent bacterial filtrates. The skin-preparatory and reacting potencies o...

tyrosinase has been recognized as a major autoantign in human vitiligo. here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete freund’s adjuvant in c57bl/6 mice. the onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. our results con...

A parasitologic survey of human parasitic infections was made in Shizuoka Prefecture, Japan, during August and September, 1950 (Ritchie et al., 1951a). The objectives included a determination of (i) the incidence of infections, (ii) helminth densities,(iii) factors predisposing infections,(iv) the status of schistosomiasis,(v) status of paragonimiasis and filariasis, and (vi) the efficiency of ...