This study sought to gain understanding of the effect of iron deficiency anemia on regional brain iron, ferritin, and transferrin concentrations in the growing piglet. We wanted to use an animal whose development is more similar to human development than rodent models. Fourteen 1-month-old piglets were used for this study. One group (n = 7) received supplemental iron (100 mg iron dextran inject...

Serum ferritin and blood haemoglobin levels were studied in 229 women attending a family planning clinic. Ferritin values ranged from 2 to 438 Jlg/l and was skewed with an arithmetic mean of 41.8 and geometric mean of 23.4 flg/l; 26.6% were iron-deficient (ferritin < 12 Jlg/l). Heamoglobin values were normally distributed with a mean of 11. 7 g/dl but 59% were anaemic (Hb < 12 gjdl]. The correl...

The literature bearing on the behavioral correlates of sideropenia in animals and man is reviewed. There is evidence to support the contention that sideropenia, per se, is causally related to the subjective complaints of the iron-deficient and/or anemic individual. And, although important biochemical pathways involving electron transport, catecholamine catabolism, and porphyrin synthesis have b...

Pseudomonas aeruginosa produces siderophores, pyoverdin and pyochelin, for high-affinity iron uptake. To investigate their contribution to P. aeruginosa infections, we constructed allelic exchange mutants from strain PAO1 which were deficient in producing one or both of the siderophores. When inoculated into the calf muscles of immunosuppressed mice, pyochelin-deficient and pyoverdin-deficient ...

Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas. In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replet...

Dear Sir: We read with great interest the article by Patterson et al (1) published recently in the Journal. In the conclusion of their abstract, the authors purport to have shown that " in iron-deficient women of childbearing age, a high-iron diet produced smaller increases in SF [serum ferritin] than did iron supplementation but resulted in continued improvements in iron status during a 6-mo f...

Erythrocyte zinc protoporphyrin (ZPP) was measured in 102 women blood donors to evaluate its usefulness in screening for evolving iron deficiency anemia, a reason for the deferral of donors. The results were compared with serum ferritin determinations. Five women were deferred before their first donation and eight women were deferred after one or two donations. Women with increased ZPP values a...

Iron transport by everted duodenal sacs in vitro was studied in mice with sex-linked anemia (gene symbol sla) (an inherited iron deficiency anemia), in normal mice, and in normal mice on iron-deficient and iron supplemented diets. Although the over-all mucosal uptake of iron was the same in sla and normal sacs, transport of iron to the inside of the sac was much decreased in sla. The iron trans...

OBJECTIVE In developing countries, many children are at high risk for both goiter and iron-deficiency anemia. Because iron deficiency may impair thyroid metabolism, the aim of this study was to determine if iron supplementation improves the response to oral iodine in goitrous, iron-deficient anemic children. DESIGN A trial of oral iodized oil followed by oral iron supplementation in an area o...