background: most cancer cells become resistant to anti-cancer agents. in the last few years, a new approach for targeted therapy of human cancer has been developed using immunotoxins which comprise both the cell targeting and the cell killing moieties. methods: in the present study, the recombinant shiga toxin a1 subunit fused to human granulocyte-macrophage colony stimulating factor (a1-gm-csf...

distal junctional kyphosis (djk) is a radiographic finding in patients that undergo spinal instrumentation and fusion, since there is an abrupt transition between fixed and mobile spinal segments.the true incidence of djk is variable in literature and seems that has a multifactorial etiology. a consecutive series of 130 patients (mean age 15.6 years) with adolescent idiopathic scoliosis who und...

diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. the potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. obesity and alignment especially varus malalignment are recognized factors of a progressive disease. both nonpharmalogical as well as pharmacological modalities of treat...

tooth fusion is a developmental anomaly characterized by the :union: between the dentin and/or enamel of at least two separately developing teeth. the fusion of posterior teeth is an uncommon occurrence. in this article, we report a rare case of unilateral fusion of a mandibular second molar with a paramolar. carious exposure mandated endodontic treatment. the unusual morphology and complex roo...

introduction arthrogryposis multiplex congenita (amc) with incidence of 1 in 3000 of births is characterized by multiple rigid joint and soft-tissue contractures. case presentation we present a case of amc with severe soft tissue and joints contractures, especially joints of lower limb and elbows, bilateral complete dislocation of hips (cdh) and knees (cdk) (type iii), bilateral elbow joint dis...

conclusions this study presented some effects of the pomegranate peel extract in reducing pain and improving clinical signs and symptoms in women with knee oa and might be considered as a complementary medicine in treating oa. results there were no significant differences between the two groups in the mean of age, body mass index (bmi), disease duration and parity before intervention (p > 0.05)...

background and aims: osteoarthritis is one of the most common arthritis in elderly. we evaluated to compare the effect of topical application of eugenia caryophylata extract and topical diclofenac in primary knee osteoarthritis.methods: this randomized double-blind clinical trial study was carried out upon 105 patients with primary knee osteoarthritis. patients were selected randomly and divide...

background intra-articular analgesia is a pain reliever that is frequently administered following arthroscopic knee surgery. objectives the purpose of this study was to compare the efficacy of intra-articular applicationrnof morphine and tramadol on postoperative pain after arthroscopic knee surgery patients and methods for this randomized double blinded clinical trial, 132 patientsrnundergoing...

  Background: The aim of this review article is to analyze the results of high tibial osteotomy compared to unicompartmental knee arthroplasty in patients with unicompartmental knee osteoarthritis.   Methods: The search engine used was PubMed. The keywords were: "high tibial osteotomy versus unicompartmental knee arthroplasty". Twenty-one articles were found on 28 February 2015, but only eighte...