Combination of lactam antibiotic with lactamase inhibitor has been proven to overcome resistance caused by lactamase production. An evaluation to the MIC of some lactam antibiotics to b-lactamase producing isolates will be reported. A.anitratus, E.coli, K.pneumoniae, Proteus sp, Pseudomonas sp, S.aureus, S.epidermidis, S.pneumoniae, S.viridans, and hemolytic Streptococcus, were challe...

Providencia rettgeri is an opportunistic bacterial pathogen of clinical significance due to its association with urinary tract infections and multidrug resistance. Here, we report the first complete genome sequence of P. rettgeri The genome of strain RB151 consists of a 4.8-Mbp chromosome and a 108-kbp blaNDM-1-positive plasmid.

Salmonella genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. A serious threat to public health was revealed in the recent description in P. mirabilis of a SGI1-derivative multidrug resistance island named PGI1 ...

The spread of carbapenemases in Enterobacteriaceae represents a global menace, with nosocomial and community-acquired New Delhi metallo-b-lactamase (NDM) Escherichia coli now on the top list of metallo-b-lactamase (MBL) producers in Europe. Medical tourism, business travel, and world-wide diaspora have played a central role in establishing secondary reservoirs [1]. The early identification of p...

OBJECTIVES A growing incidence of pathogens producing carbapenemases has been observed in many countries including Bangladesh. The present study was carried out to determine the presence of carbapenemase producers among uropathogens. MATERIALS AND METHODS A total of 138 Gram-negative uropathogens were isolated and identified by conventional methods and were screened for carbapenemase producti...

INTRODUCTION The present study attempts to examine the microbial profile and antibiotic susceptibility of diabetic foot infections in the intensive care unit of a tertiary referral centre for diabetic foot. As part of the study, we also attempted to find the prevalence of blaNDM-like gene among carbapenem-resistant gram negative infections. METHODOLOGY A prospective study of 261 patients with...

During the last years, outbreaks and countrywide spread of isolates producing -lactamases of the AmpC type or carbapenemases have been reported (1, 2). We detected three Proteus mirabilis isolates with reduced susceptibility to cephalosporins and carbapenems at the Alexandrovska University Hospital in Sofia. They were isolated between November 2011 and January 2012 from the urine of three patie...