Our knowledge of the genetic basis of these disorders began in 2005, when a unique base substitution in JAK2, the gene encoding Janus kinase 2,was found inpatientswith polycythemia vera, essential thrombocythemia, and primary myelofibrosis. The background of our investigations was the previous finding that copy-neutral loss of heterozygosity of chromosome 9p (9pLOH) is the most common chromosom...

STATEMENT OF THE PROBLEM Aloe vera gel contains various components with antibiotic and anti-inflammatory characteristics, which may have potential advantages to treat periodontal diseases. PURPOSE The aim of this study was to evaluate the effects of local application of aloe vera gel as an adjunct to scaling and root planning in the treatment of patients with chronic periodontitis. MATERIAL...

The tree species, Pistacia vera (P. vera) is an important commercial product that is salt-tolerant and long-lived, with a possible lifespan of over one thousand years. Gene expression analysis is an efficient method to explore the possible regulatory mechanisms underlying these characteristics. Therefore, having the most suitable set of reference genes is required for transcript level normaliza...

Background. The use of aloe vera is being promoted for a large variety of conditions. Often general practitioners seem to know less than their patients about its alleged benefits. Aim. To define the clinical effectiveness of aloe vera, a popular herbal remedy in the United Kingdom. Method. Four independent literature searches were conducted in MEDLINE, EMBASE, Biosis, and the Cochrane Library. ...

for centuries, aloe vera has been used by many different cultures. the ancient greeks, the romans, the babylonians, indians and the chinese have all used aloe vera as a medicinal plant. one of the common experimental cancer models is sarcoma-180. when aloe was administered to mice bearing s-180 tumors, the tumor growth was inhibited. aloe vera is a dietary supplement and not a regulated drug. t...

dum-Nielsen K. Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Leukemia 2002;16:1390-3. 44. Cashman J, Henkelman D, Humphries K, Eaves C, Eaves A. Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny. Blood 1983;61:876-84. 45. Levin J, Cocault L, Demerens C, Challier C, Pauchard...

Removing the bacteria, including Enterococcus faecalis, from the root canal is one of the important aims in endodontic treatment.We aimed to compare the antibacterial activity of Chlorhexidine with two natural drugs. The antibacterial activities of three different propolis extracts (alcohol concentrations: 0, 15, 40%) and Aloe vera gel on E. faecalis were compared using three methods: disk dif...

objective: profound consumption of medicinal plants products worldwide and public misconception of the products safety puts the urgent need forward as to evaluation of their safe and harmful aspects. in the present study the lavandula angustifolia essential oil was studied with a view to the foregoing criteria. materials and methods: the antimicrobial, antioxidative, hematologic and cytotoxic ...

The aims of this study are to determine the chemical composition of Lavandula angustifolia Mill. and Coriandrum sativum L. essential oils, to evaluate their cytotoxic effects in SH-SY5Y human neuroblastoma cells, to investigate whether an alteration of adenylate cyclase 1 (ADCY1) and of extracellular signal-regulated kinase (ERK) expression can take part in the molecular mechanisms of the essen...

This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae) was identified, and we analy...