During early limb development, distal tip ectoderm is induced by the underlying mesenchyme to form the apical ectodermal ridge. Subsequent limb growth and patterning depend on reciprocal signaling between the mesenchyme and ridge. Mice that are homozygous for mutations at the limb deformity (ld) locus do not form a proper ridge and the anteroposterior axis of the limb is shortened. Skeletal ana...

Knowledge of the profile of congenital limb defects in a population is important in informing their prevention, management and rehabilitation strategies. The profile displays geographical and ethnic variations. There are few reports from African countries, most of them being case reports. This study aimed at reporting congenital defects of lower limb observed in a rural hospital in Kenya. Recor...

INTRODUCTION The occurrence of internal hernia is not an uncommon late complication following the laparoscopic bariatric Roux-en-Y gastric bypass procedure. In some instances, it can be life threatening if not treated in a timely manner. Although there are numerous publications in the literature addressing internal hernia, they are mostly retrospective, and focus mainly on describing the differ...

Submit Manuscript | http://medcraveonline.com sometimes it may occur as an autosomal dominant trait [1,2]. Klippel-Trenaunay-Weber Syndrome is a cutaneous vascular malformation affecting the development of blood vessels, soft tissues and bones [3]. This is a non-heritable disorder which is present at birth and usually involves lower limb but may involve more than one limb and a portion of the t...

We describe the management of nonunion combined with limb-length discrepancy following vascularised fibular grafting for the reconstruction of long-bone defects in the lower limb after resection of a tumour in skeletally immature patients. We operated on nine patients with a mean age of 13.1 years (10.5 to 14.5) who presented with a mean limb-length discrepancy of 7 cm (4 to 9) and nonunion at ...

BACKGROUND Limb-sparing surgeries around the shoulder girdle pose a surgical difficulty, because tumors arising in this location are frequently large at presentation, are juxtaposed to the neurovascular bundle, require en bloc resection of proportionally large amounts of bone and soft tissues, and necessitate complex resection and reconstruction. STUDY DESIGN Between 1980 and 1997, we treated...

Abstract Background With the development of medical technology, credible options for defect reconstructions after resection benign bone tumors lower extremities have become a high priority. As current reconstructive methods commonly used in clinical practice some flaws, new reconstruction need to be explored. We aimed prepare kind bioactive scaffold repair defects through stem cell rapid screen...

To describe the differences in knee structure and non-knee structural factors between offspring having at least one parent with a total knee replacement for severe primary knee osteoarthritis and age- and sex-matched controls with no family history of knee osteoarthritis, a population-based longitudinal study of 163 matched pairs (mean age 45 years, range 26 to 61) was performed at baseline and...

Background: Tendon defects remain a major concern in orthopedic surgery because of the limited availability of tendon autografts. Since the extracellular collagen-based matrix derived from porcine small intestinal submucosa (SIS) has been successfully used in repair of many tissues, such as abdominal wall, vessels and bladder, we hypothesized that SIS can be used to repair an experimentally ind...