Background: Oxidative stress, lipid profile and renal functions are well-known conventional risk factors for diabetes mellitus (DM). Metformin gliclazide popularly used monotherapy drugs the treatment of DM. Aims: This study aims to assess short-term single dual therapy glipizide/metformin on oxidative glycemic control, serum profiles function in diabetic rats. Methods: DM was induced rats with...

BACKGROUND Glycowithanolides (Withaferin A), is one of the main withanolides active principle isolated from plant Withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties. OBJECTIVE In the present investigation, antioxidant activity of active principles of Withania somnifera was tested against D-galactose induced oxidative stress i...

Objective: Ethanol extract of Cajanus cajan (L.) Millsp. (Pigeonpea) leaves (ECC) was investigated for its hepatoprotective activity. Methods: Different groups of Wistar albino rats were administered with paracetamol (500 mg/kg, p.o., once daily for 7 days) for induction of hepatotoxicity. ECC (100, 200 and 300 mg/kg/day) and silymarin (25 mg/kg/day) were administered to the paracetamol induced...

BACKGROUND Fenton reaction (Fe2++H2O2→Fe3++•OH+OH-) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid hormone synthesis. Also iodine, an essential element supplied by the diet, is indispensable for thyroid hormone synthesis. It is well known that iodine affects red-ox balance. One of the most frequently examined oxidative proce...

BACKGROUND Oxidative stress mechanisms are involved in the pathophysiology of many reproductive disorders. The objective of this study was to characterize oxidative stress parameters in hydrosalpingeal fluid (HSF) and examine their possible role in early embryo development. METHODS AND RESULTS HSF was aspirated at laparoscopic salpingectomy in 11 infertile women. Reactive oxygen species (ROS)...

Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO. To determine whether amyloid beta (Abeta) deposition in vivo is associated with increased LPO, we examined iP levels in a transgenic mouse model (Tg2576) of AD amyloidosis. Urine, plasma, and brain tissues were c...

The article presents the results of studies dependence cows’ milk productivity on level lipid peroxidation and antioxidant defense in their body. For experiment two groups lactating cows were formed, 10 animals each: group 1 – livestock with a high concentration products blood low antioxidants; 2 values these indicators within reference interval. research indicate that average daily yield was l...

The formation of Lewy bodies containing α-synuclein (α-syn), prominent loss of dopaminergic neurons and dopamine (DA) deficiency in substantia nigra and striatum are histopathological and biochemical hallmarks of Parkinson's disease (PD). Multiple lines of evidence have indicated that a critical pathogenic factor causing PD is enhanced production of reactive oxygen species (ROS), which reacts r...

BACKGROUND This work aims to investigate the role of lipid peroxidation (LPO) at early stages of liver regeneration and to evaluate the balance between apoptosis and cell proliferation during this process. METHODS Sham and partial hepatectomized (PH) male Wistar rats were randomized in seven groups: Control (untreated), E-Control (injected with vitamin E-vehicle), C-Control (injected with vit...