Liver cancer is one of the most common malignant solid organ tumors. This associated with a high death rate. At present, it possible to investigate functional dysfunction module hepatocellular carcinoma (HCC) using genetic characteristics liver tissue, revealing its pathogenesis and guiding tailored management therapy. It not only provides important information for additional diagnostic therapy...

The purpose of this study was to evaluate the effects of aluminum on the tissue enzymes of gills, liver and muscles in common carp. In this study, the effects of sub lethal levels of aluminum on metabolic enzymes, Aspartate aminotransferase, Alanine aminotransferase and alkaline phosphatase (AST, ALT and ALP) in organs including gills, liver and muscles of common carp (Cyprinus carpio) were eva...

Objective(s): Methylsulfonylmethane (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. In this study the effect of MSM pretreatment on acetaminophen induced liver damage was investigated. Materials and Methods: Male Sprague Dawley rats were pretreated with 100 mg/kg MSM for one week. On day seven rats were received ace...

Introduction: Rifampin is one of the common drugs used to treat tuberculosis and considered a strong toxic agent for liver. The aim this study investigate effects cinnamon extract administration on rifampin-induced hepatotoxicity in rats. Materials methods: In experimental study, 60 male Wistar rats were randomly divided into 6 groups. Liver damage induction oxidative stress caused by 80 mg/kg/...

In acute experiments on laboratory rats, intra-portal administration of L-cysteine (20 mg/kg), the precursor hydrogen sulfide synthesis, stimulated oxygen consumption liver by 38.6% and reduced tension 37.1%. Activation tissue respiration occurred due to strengthening oxygen-dependent synthetic processes in liver, particular those associated with mitochondrial enzyme-catalysed bile acid biosynt...

abstract pollution is a world problem with serious consequences. heavy metals are an important group of these contaminants and enter aquatic ecosystems from anthropogenic and natural sources and animal health and systems are affected. in this study, the effect of lead exposure (3 mg/l concentration, 30 days) on activity of tissue enzymes, including acetyl cholinesterase, alanine aminotransferas...

abstract since gasoil due to the aromatics of the most important environmental pollutants and is one of the oil with many applications. according to its damaging effects on living organisms and human beings, the purpose of this study was to investigate the effects of gasoil on the parameters of liver, white rat race was albino nmri. the 40 mice in 4 groups, adult male mice were divided into con...

The purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or oneweek. Hepatic enzymes containi...

Objective(s): Iranian crack (IC) is a heroin-based substance manifesting various pathologic side effects. Herein, we aimed to investigate the mechanism of IC-induced liver injuries in Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly divided into two groups: control, and IC (0.9 mg/kg/day/IP, for 30 days). Mitochondrial reactive oxygen species (ROS) production was measur...