P Ph Pharmace ce ceut utic ic cal al a S Sci ci ien en ence ce ce, , Ki Ki ing ng ng's 's C Col olle lege ge g L Lon o do do don, L Lon on ondo do d n, U U UK; K; K; 3 Mo Mo ode d l An An nsw sw swer ers s Pt Pt ty y y Lt Lt Ltd, d, d B B Brisb ba ban ne, Au Au A st stra ra rali li lia a Ad Addr dres ess s fo for r Co Corr rres espo pond nden ence ce: : Abstract: Background—The optimal dosing s...

Hemorheological studies were made on surface layers of solutions of highly purified human fibrinogen, to which low molecular weight (LMW) heparins, as well as chondroitins A, B and C were added. The surface viscous (eta's) and elastic (Gs) moduli of these fibrinogen systems were measured with a modified Weissenberg Rheogoniometer. Our findings show that n's and Gs of these heparin-fibrinogen an...

BACKGROUND During haemodialysis, anticoagulants are required to prevent clotting in the extracorporeal circuit. Low-molecular weight heparins (LMWH) are frequently used because of the ease of a single injection at the start of dialysis. Disadvantages of LMWH include the lack of a reliable bedside assay for measuring their anticoagulant effect. METHODS We investigated a bedside test for LMWH a...

A novel method has been developed for the easy measurement of heparin's anticoagulant activity using surface plasmon resonance. The anticoagulant activity of target heparin was evaluated by measuring the competitive antithrombin III binding of analyte heparin in the solution phase and USP heparin immobilized on chip surface. Heparins, obtained from different animal sources, and low molecular we...

OBJECTIVE To investigate tolerability and efficacy of low molecular weight (LMW) heparin therapy in patients with severe Raynaud's phenomenon. METHODS A prospective parallel group study comparing patients receiving regular subcutaneous LMW heparin (n = 16) with a matched control group (n = 14). Endpoints were change in Raynaud's attack severity, non-invasive vascular studies or serum levels o...

anticoagulation drugs are frequently used to prevent deep vein thrombosis in high-risk patients. subcutaneous low molecular weight heparin (lmwh) is increasingly used in both hospitalized patients and outpatient settings. this necessitates familiarity of both health care providers and patients with such treatment and vigilance on possible complications. here we present a case of hematoma of rec...

Oral anticoagulation with a vitamin K-antagonist requires special consideration when surgery or interventional procedures are planned. This is mainly due to the half life of vitamin K-antagonists and to the need for safe and effective anticoagulation prior to and during surgery as well as in the postoperative period. So far, the continuous infusion of unfractionated heparin (UFH) has been the m...

BACKGROUND The purpose of this study was to stratify plastic surgery patients into venous thromboembolism risk categories; identify patients at highest risk for venous thromboembolism; and quantify rates of postoperative all-cause mortality, venous thromboembolism, and hematoma/bleeding on different forms of thromboprophylaxis. Furthermore, this study aimed to determine the compliance and avera...