Common techniques for the treatment of Hepatocellular carcinoma (HCC) have not been successful, and thus the design and discovery of new compounds with better anti-cancer function are needed. Snake venom is among the most important compounds used by researchers to the treatment of various cancers. This study was designed to evaluate the toxicity effect of Persian Gulf snake venom (Enhydrina sch...

Background: Mitochondria are a source of reactive oxygen species (ROS), and several natural compounds used as antioxidant agents. This study aimed to investigate compare the effects fresh grape juice red wine on oxidative stress biomarkers in rat liver mitochondria. Materials Methods: In this regard, mitochondria were isolated from 27 male Wistar rats (220-250 g). The cultured different doses f...

The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed overcome this disease. In review, researchers collected information about dysfunctional energy in diseases driven by mitochondria. Mitochondrial dysregulation can cause damage the neuron system. amount and interaction α-synuclein SAMM50 GABARAPL1 mitochondria one factors causing As ...

Mitochondria are one of the most important organelles for eukaryotes, including humans, to produce energy. In energy-producing process, mitochondria constantly generate reactive oxygen species as a by-product electrons leaking out from electron transport chain react with oxygen. The active oxygen, in turn, plays pivotal roles mediating several signalings, those that implicated development some ...

Cancer is a heterogeneous and complex genetic disease. In addition to genetic mutations in oncogenes and tumour suppressors, the onset and progression of cancer is also bound to the cancer cell’s microenvironment. After many years of ostracism the energetic metabolism of cancer [1] has been accepted as an additional hallmark of the cancer phenotype [2] and mitochondrial/ glycolytic studies have...

conclusion lesion depth from the pleural surface and the presence of emphysema were strongly correlated with the increasing incidence of pneumothorax after ct-guided pcnb. our results may be applicable for the risk management of pcnbs to reduce pneumothorax as a complication. background previous studies identifying risk factors for pneumothorax in percutaneous core needle lung biopsies reported...

According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives (6aa–6gc) have been synthesized by combinations various 1,5-diarylpyrazole-3-carboxylic acids with secnidazole. The in vitro antitumor/cytotoxicities activities against tumor and normal cell lines, including NCI-H460 (lung cell), MCG-803 (gastric Skov-3 (ovarian BEL-740...

objective: the urinary system of euryhaline fish, as well as the gills, is involved in ion regulation through the production of dilute urine in freshwater and isotonic urine in seawater. the low osmolality of the urine originates from an active reabsorption of ions by ionocytes or mitochondria rich-cells (mrcs) present in certain parts of the urinary system. mitochondria rich-cells possess a hi...

The International Agency for Research on Cancer (IARC) declared arsenic a class I carcinogen. Arsenic exposure induces several forms of human cancers, including cancers of skin, lung, liver, and urinary bladder. The majority of the arsenic-induced cancers occur in skin. Among these, the most common is Bowen's disease, characterized by epidermal hyperplasia, full layer epidermal dysplasia, leadi...

Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. Snn is localized in tissues with known sensitivity to trimethyltin (TMT), including the central nervous system, immune system, spleen, kidney and lung. Cells in culture that do not express Snn show considerable resistance to TMT toxicity. In vitro, Snn peptide can bind TMT in a 1:1 ...