Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...

edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. paraquat (pq) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to pq toxicity. in this study, protective effect of edaravone against pq induced toxicity and reactive oxygen species (ros) generation in a549 cells and...

Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

previous studies demonstrated that cse induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of cse in human health and disease. the present study was carried out to further characterize and compare toxic effect of cse extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Lung cancer is the most commonly diagnosed with a high mortality rate. Cisplatin one of important chemotherapeutic agents for treatment lung patients, especially in advanced stages. Recent studies show that cisplatin may interact mitochondria to induce apoptosis, which partly account its cytotoxicity. In study, we explored effect resistin on cisplatin-induced cytotoxicity A549 cells and assesse...

Lung Cancer Metabolic reprogramming is a hallmark of metastatic lung cancer cells (A549_3R). In article number 2200050, Victor Shahin and co-workers establish that 5-7 carbon glycols reduce the A549_3R ATP production by interfering with LDH mitochondria. The cover image reveals decline in mitochondrial membrane potential when exposed to 1,6-HD.

mitochondrial space was not completely reduced. This indicates some mitochondrial oxidative activity when alveolar Po, was in the 0.5-1.0 mrn Hg range. These studies have demonstrated substrate oxidation and respiratory control with isolated lung mitochondria. Measurements of surface fluorescence and tissue redox couples show intracellular reduction of pyridine nucleotides in response to oxidat...