Psychogenic excoriation (PE), characterized by excessive scratching or picking of the skin, is not yet recognized as a symptom of a distinct DSM-IV disorder. It is a chronic disorder with a high rate of psychiatric comorbidity. The purpose of this study was to compare patients diagnosed with PE and patients with another dermatological disease in terms of comorbid psychiatric disorders. Thirty-o...

Creutzfeldt–Jakob disease (CJD) is a rare, progressive, and fatal prion disease. Often the first sign of CJD rapidly progressive dementia, leading to memory loss, personality changes, hallucinations. Myoclonus typically occurs in 90% cases, but often may not be an initial symptom. Other frequently occurring psychiatric symptoms include depression, anxiety, paranoia, obsessive-compulsive symptom...

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS) provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context for interpreting MRS studies of neuropsychiatric disorders, we review the characteristic MRS signals, the metabolic dynamics,and the neurobiological significance of the major brain metabolites that can be measured using clin...

At present, there are more small, open-label trials than large, double-blind, placebo-controlled studies of atypical antipsychotics in the treatment of nonpsychotic psychiatric illnesses. Existing evidence indicates both the safety and the efficacy of relatively low doses of the dopaminergic/serotonergic atypical antipsychotics as adjunctive, or augmentation, therapy for patients with nonpsycho...

We conducted a meta-analysis of randomized trials in which the effects of treatment with antidepressant medication were compared to the effects of combined pharmacotherapy and psychotherapy in adults with a diagnosed depressive or anxiety disorder. A total of 52 studies (with 3,623 patients) met inclusion criteria, 32 on depressive disorders and 21 on anxiety disorders (one on both depressive a...

Abstract Cyberbullying contributes to poor mental health outcomes and quality of life (QoL), peer victimisation has been shown be positively associated with both positive negative metacognition. Whilst metacognitive beliefs are pathological worry, obsessive–compulsive symptoms, rumination in depression, research is yet examine whether influence outcomes, such as reduced QoL, experiences cyberbu...

OBJECTIVE An anxiety disorder severely affects the sufferer's quality of life (QOL), and this may be particularly true of those with obsessive-compulsive disorder (OCD). This study examines the differential impact of obsessions, compulsions, and depression comorbidity on the QOL of individuals with OCD. METHOD Forty-three individuals diagnosed with OCD according to DSM-IV criteria and experie...

Depression commonly is comorbid with epilepsy and, of the depressive disorders, major depression is most common. Depression is often comorbid with an anxiety disorder (eg, generalized anxiety, social phobia, post-traumatic stress disorder, panic disorder, or obsessive-compulsive disorder), in the general public and in persons with epilepsy (PWE). This discussion will focus on mood disorders in ...

Data from the Children in the Community Study, a prospective longitudinal investigation, were used to investigate the association of personality disorder (PD) traits, evident by early adulthood, with risk for the development of unipolar depressive disorders by middle adulthood. Antisocial, borderline, dependent, depressive, histrionic, and schizotypal PD traits, identified between ages 14 and 2...