We evaluated the effect of tamoxifen (TAM) on tumor development in proto-neu transgenic mice that spontaneously develop mammary carcinomas overexpressing the neu protein. These mammary carcinomas are hormone independent because superimposable growth of transplants was observed in females and males. Virgin transgenic mice treated with TAM from 24 weeks of age, ie., when subclinical mammary tumor...

Metastasis, the spread of tumor cells from the primary site to lymph nodes and the distant organs is the most aggressive and specific feature of malignant cancer. The mechanisms by which malignant cells leave the primary tumor, invade lymphatics and metastasize are complex and interconnected being directly related to biological behavior of tumor. However, the lymphatic vasculature is often negl...

Background: Antipsychotic drugs are medications used to treat schizophrenia and other psychotic disorders. Antipsychotic drugs can cause unwanted side effects. Hyperprolactinemia is an important but neglected adverse effect. The aim of the this study was to consider the effects of Chlropromazine -induced hyperprolactinaemia on mammary glands of female rats . Materials and Methods: In this study...

The protein deacetylase SIRT1 has been implicated in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. There are conflicting data that make it unclear whether Sirt1 functions as an oncogene or tumor suppressor. To assess the effect of SIRT1 on the emergence and progression of mammary tumors, we crossed mice that harbor ...

1 univ. of Ljubljana, Biotechnical Fac., Dept. of Animal Science., Groblje 3, SI-1230, Slovenia, e-mail: [email protected] 2 Same address as 1, e-mail: [email protected] Mammary tumors in ruminants The frequency of mammary neoplasia in different species varies tremendously. Among women, breast cancer features as one of the most frequent types of cancer globally. Breast cancer is th...

Wnt ligand–driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an acute and strong induction of insulin-like growth factor (IGF)– binding protein IGFBP5, an antagonist of IGF signaling that mediates involution of ma...

The isolation and characterization of mammary stem cells is fundamental to understanding mammary gland development and tissue homeostasis as well as breast oncogenesis. Recent studies have led to the prospective isolation of pluripotential stem cells from the mouse mammary gland through the identification of specific cell-surface markers and transplantation of cells into the mammary stromal mic...

The influence of caffeine consumption on the development of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in BD2F1 female mice and spontaneous mammary carcinomas in nulliparous C3H mice was examined. Caffeine (250 and 500 mg/liter of drinking water) was administered to BD2F1 mice commencing 1 week after a series of 6 weekly 7,12-dimethylbenz(a)anthracene intubations, until experimen...

Mammary carcinoma is one of the most common skin tumors mammary gland area in canine. Fifty cases were reported during period study at Teaching Veterinary Clinical Complex and Department Surgery Radiology. Eighty animals screened for selecting fifty these are subjects present population. The prevalence across age groups highest among 8 to 12 years, followed by years least dogs below years. Bree...

Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days 7 and 20 to 10 microg 17beta-estradiol (E2) reduced later risk of developing 7...