Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of ...

Cell Tracking In article number 2207626, Jeff W.M. Bulte, Chao Wang, and Ali Shakeri-Zadeh review the occasional adverse effects encountered with magnetic labeling of cells for in vivo cell tracking using resonance imaging (MRI) particle imaging. Mesenchymal stem (MSCs) are abundant mannose residues on their membrane. Using mannose-sensitive chemical exchange saturation transfer MRI, MSCs is no...

background: mesenchymal stem cells (mscs) are multipotent cells, capable of differentiating into different cell lines.they can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. therefore, the exposure of these cells to endothelial growth factor (vegf) as well as hemodynamic biomechanical forces, which act on...

Umbilical cord blood (UCB) has been used for transplantation in the treatment of hematologic disorders as a source of hematopoietic stem cells (HSCs). Because of insufficient number of cord blood CD34+ cells, the expansion of these cells seems to be important for clinical application. Mesenchymal stromal cells (MSCs), playing an important role in HSCs maintenance, were used as feeder layer. Apo...

Currently, it has been suggested that human mesenchymal stem cells (MSCs), a well-known multipotent cells, could modify the biological process in leukemia cells. Therefore, we evaluated MSCs’ possible effects on apoptosis and proliferation of acute lymphoblastic (ALL) MOLT-4 Accordingly, were co-cultured with MSCs. Then, 24, 48, 72 hours after treatment, percentages cell was estimated using flo...

Human mesenchymal stem cells (MSCs) have huge potential for regenerative medicine. In particular, the use of pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) overcomes the hurdle of replicative senescence associated with the in vitro expansion of primary cells and has increased therapeutic benefits in comparison to the use of various adult sources of MSCs in a wide range of anima...

background: the definitive endoderm (de) differentiation using the undefined media and non-human feeders can cause contaminations in the generated cells for therapeutic applications. therefore, generating safer and more appropriate de cells is needed. this study compared five different methods to establish an appropriate method for inducing an efficient de differentiation from human induced plu...

In order to study the effects of Senolytic drugs dasatinib and quercetin on aging mesenchymal stem cells (MSCs) explore application young MSCs in repairing bone defects, cultured identified were treated with quercetin, counting number passage times, senescence was evaluated by high-content screening microscopy. The 4th-passage rejuvenated transplanted into defect model rabbits, X-ray examinatio...

Mesenchymal stromal cells (MSCs) are one of the most intensively studied stem cell types with application aims. However, the molecular characterisation and the relationship between the molecular characterisation and functional properties of MSCs are largely unknown. In this study, we purified the surface proteins from rat bone marrow MSCs (rBMMSCs) and characterised their surface proteome by LC...

Imbalance in immune responses plays an indispensable role pathogenesis and development of multiple sclerosis (MS), as a neurodegenerative disorder. Current treatments are not always successful preventing MS treating the disease. Stem cell-based cell therapy has provided new window for disorders. cells can regulate system improve axonal remyelination. They be isolated from different origins such...