Both acute and chronic stress can impair maternal behavior and increase rates of infant abuse in several species. The mechanisms inducing these effects are unknown, but experimental manipulation of circulating corticosterone levels alters maternal behavior in rats, and circulating or excreted cortisol concentrations have been found to correlate either positively or negatively with maternal beha...

In the central nervous system, electrogenic sodium- and potassium-coupled glutamate transporters terminate the synaptic actions of this neurotransmitter. In contrast to acidic amino acids, dicarboxylic acids are not recognized by glutamate transporters, but the related bacterial DctA transporters are capable of transporting succinate and other dicarboxylic acids. Transmembrane domain 8 contains...

A 64-year-old man who was receiving chemotherapy for gastric cancer with liver metastases was referred to our department for an allergy workup after experiencing a skin reaction. The chemotherapy regimen comprised taxotere, oxaliplatin, and 5uorouracil (5-FU) (combined with calcium folinate) followed by abundant intravenous hydration. Each cycle was administered in combination with a standard p...

Phase diagrams and the compositions of coexisting phases of poly(ethylene glycol) (PEG) 6000 + sodium succinate + water system have been determined experimentally at 298.15, 308.15, and 318.15 K. The effects of temperature on the binodal curve and tie lines have been studied. The binodal curves were successfully fitted to a nonlinear equation relating the concentrations of PEG 6000 and sodium s...

OBJECTIVES The aim of this study was to test whether peroxynitrite neutralizers would reduce peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation in endotoxin-treated rats. BACKGROUND Release of endogenous proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha in response to endotoxin is responsible for the production of large amounts of nitr...

Four kinds of modified starches that are expected to improve the quality crystal dumpling skins were selected, namely Potato acetate starch, hydroxypropyl Octenyl succinate starch sodium, Acetate cassava starch. Through determination physical indicators above four starches, and then explore feasibility applying them their quality. Studies have found light transmittance is higher than original m...

This report examined the effect of corticosteroids in vitro on human peripheral blood monocytes, essential cells in both immune and nonimmune cellular defense mechanisms. Monocyte chemotaxis in response to sera, Escherichia coli filtrate, and lymphokine chemotactic factor was markedly reduced (P < 0.01) by hydrocortisone succinate (HCS) at 16 mug/ml. Methylprednisolone succinate and unesterifie...

this study was conducted to investigate the correlation between lipid-lowering and bone-protective effects of eicosapentaenoic acid on steroid-induced bonechanges in rats. twenty-one male 10-week-old wistar rats were divided into 3 groups (n = 7 each) and treated with 0.9% nacl sc (group 1) or methylprednisolone 7 mg/kg sc once a week (group 2) or methylprednisolone 7 mg/kg sc once a week + eic...

Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

The patient is 32-year-old, male who had been administered sodium bicarbonate and a small dose of a-mercaptopropionylglycine under the diagnosis of cystinuria, but during the 8th year of treatment he developed nephrotic syndrome. He suffered a number of recurrences which were treated each time with steroid only, but complete remission of nephrotic syndrome was achieved with the combined adminis...