Auditory brain-stem responses (ABRs) were studied in 66 subjects with severe head trauma. Middle latency responses (MLRs) were also recorded in 22 of them. Patients were carefully selected to avoid conditions such as pre-existing or acute deafness, hypothermia or ethanol intoxication. In order to evaluate the usefulness of potentials in predicting recovery, patients were classified according to...

The present study deals with the estimation of the anti-HIV activity (log1/C) of a large set of 107 HEPT analogues using molecular descriptors which are responsible for the anti-HIV activity. The study has been undertaken by three techniques MLR, ANN, and SVM. The MLR model fits the train set with R (2)=0.856 while in ANN and SVM with higher values of R (2) = 0.850, 0.874, respectively. SVM mod...

Several variants of randomization procedures were compared as a tool in validation of multilinear regression (MLR) QSAR equations that are obtained by descriptor selection. Y-randomization, a method formerly said to be probably the most powerful validation procedure, was found to be overoptimistic. The statistical significance of a new MLR QSAR model should be checked by comparing its measure o...

In this paper we propose a framework for defining and discovering optimal association rules involving a numerical attribute A in the consequent. The consequent has the form of interval conditions (A < x, A x or A ∈ I where I is an interval or a set of intervals of the form [xl, xu)). The optimality is with respect to leverage, one well known association rule interest measure. The generated rule...

In this work multiple linear regression (MLR) and artificial neural network (ANN) were used to predict the retention factors of 40 basic and neutral drugs in immobilized artificial membrane liquid chromatography. Two separate models were developed for prediction of solute retention in two mobile phase compositions which were used five identical descriptors. The standard errors in ANN calculatio...

It is now well recognized that pre-transplant donor-specific blood transfusion (DST) has a beneficial effect on the survival of allografts. To determine the optimal interval between DST and transplantation, and to analyze the mechanisms of this effect, the survival of cardiac allografts to rats which received a single DST was examined. The cardiac allograft survival was found to be prolonged wh...

The effect of three membrane-stabilizing agents, chlorpromazine, imipramine, and lidocain, on in vitro activation of cellular responses was studied using the one-way MLR. Cellular activation was found to be depressed by these drugs. However, the degree of suppression paralleled the decline of viable cells in the cultures. It is concluded that drug-induced inhibition of MLR was due solely to the...

one of the most important aspects of software project management is the estimation of cost and time required for running information system. therefore, software managers try to carry estimation based on behavior, properties, and project restrictions. software cost estimation refers to the process of development requirement prediction of software system. various kinds of effort estimation patter...

The measurement and prediction of dye concentration is important in the design, planning and management of wastewater treatment. Soft computing techniques can be used as a support tool for analyzing data and making prediction. In this study, Central Composite Design (CCD) and adaptive neuro-fuzzy inference system (ANFIS) are employed to identify and predict the output intensity ratio of light t...