Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of extinction. In experiment 1, rats were conditioned to fear a tone conditional stimulus (CS) and subsequently extinguished either in the same context as con...

Colocalization of indoleamine uptake and GABA-like immunoreactivity was studied in the cat retina. Consecutive, semithin sections were incubated in antisera to either 5-HT (5-hydroxytryptamine) or GABA. More than 90% of all 5-HT-accumulating amacrine cells expressed GABA-like antigens. With the same approach, the colocalization of 5-HT uptake and GABA-like immunoreactivity was studied in rabbit...

introduction: aggressive behavior is a major issue in the field of mental health. pharmacotherapy is often used for the treatment of violent individuals. a neurochemical system most consistently linked with aggression is the gabaergic system. the aim of the present investigation was to examine the effect of muscimol (gabaa agonist) 250 and 500 ng/rat and picrotoxin (gabaa antagonist) 1.5 and 3 ...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...

Sodium-independent [ZH]GABA and [3H]muscimol binding was determined in adult rat cerebral cortical and spinal cord membranes and in membranes from fetal mouse cortical and spinal cord neurons in primary dissociated cell culture. In adult rat cerebral cortical membranes, [aH]GABA bound to two sites (Ka -8 nM, Bmax -0.62 pmol/mg protein; Ka : 390 nM, Bmax -3.9 pmol/mg protein) whereas the GABA ag...

No significant difference could be detected either by clinical impression or statistical analysis in the relief of pain afforded by 2.5 mg phenazocine hydrobromide (Narphen) and 10 mg morphine sulphate when given by intramuscular injection to patients with acute abdominal pain. Phenazocine does not cause spasm of the sphincter of Oddi and so is recommended for treating biliary or pancreatic pain.

Description Charged MTS reagents Positively charged reagent that reacts very rapidly and specifically with cysteine groups. Useful tools for protein (transporters, receptors...) structure and activity studies These reagents would fit inside a cylinder about 0.6nm in diameter and 1nm in length (Akabas . MTSEA UP996180 100mg 500mg 1g 2-Aminoethyl MethaneThioSulfonate Hydrobromide CAS [16599-33-0]...