Background and Aims: Congenital factor V (FV) deficiency is a rare bleeding disorder with 1 in 1000000 persons in the general population. Individuals with FV activity <1% and very low FV antigen levels are characterized as severe FV deficient patients. Little data is available about the molecular basis of this bleeding disorder in Iran. Materials and Methods: We analyzed 7 unrelated Iranian FV...

Chinese narcissus (Narcissus tazetta var. chinensis) was introduced to China 1300–1400 years ago, and has grown naturally in southeastern China. It is a popular traditional potted flower well-known flowering bulb cultivated worldwide with only two white-tepal triploid cultivars, ‘Jinzhan Yintai’ ‘Yulinglong’. Recently, mutant yellow tepals observed promptly became popular. To clarify the key pi...

Mucormycosis is a life-threatening opportunistic infection caused by certain members of the fungal order Mucorales. This associated with high mortality rate, which can reach nearly 100% depending on underlying condition patient. Treatment mucormycosis challenging because these fungi are intrinsically resistant to most routinely used antifungal agents, such as azoles. One possible mechanism azol...

Abstract QUESTION The role of temozolomide chemotherapy alone in isocitrate dehydrogenase (IDH)-mutant astrocytomas has not been conclusively determined. Recent studies have linked therapy with induction hypermutation and poor clinical course some IDH-mutant gliomas. METHODS In this retrospective, single-center study, 183 patients astrocytoma, IDH-mutant, CNS WHO grade 2 or 3 diagnosed between ...

Mutant TP53 has been demonstrated to be a promising biomarker as it is the most frequently mutated gene in human cancer. However, quantifying mutation presents two unique challenges: broad concentration range and ultralow abundance. This study reports on development of an ultrasensitive highly-selective electrochemical biosensor for rapid detection blood. analysis based network gold-coated magn...