Quinones such as 1,4-naphthoquinones are abundant in nature and naphthoquinone based natural products are known to possess anticancer activity. This pharmacophore is known to convey anticancer activity to some drugs such as streptonigrin, mitomycin A, etc. We synthesized and characterized different classes of naphthoquinone derivatives including bis naphthoquinone, 2-arylaminonaphthoquinone, be...

cross-linked polymeric organogels have attracted much attention in recent years. most synthesized organogels are based on low molecular weight or denderitic materials. the study focuses on the preparation of an alcohol absorbent organogel based on 2-acrylamido-2-methylpropane sulphonic acid (amps) through cross-linking polymerization. polyethylene glycol diacrylate-400 and ammonium persulphate ...

The essential oils of the flowering aerial parts of two Ocimum species viz., Ocimum gratissimum and O. sanctum were analyzed by gas chromatography and gas chromatography/mass spectroscopy. The principal constituent of O. gratissimum and O. sanctum was eugenol (75.1%) and methyl eugenol (92.4%), comprising 99.3 and 98.9% of the total oils, respectively. In vitro antimicrobial activity of the ess...

Palm oil is one of the major oils and fats produced in world today. The quality palm crucial to be investigated, indices free fatty acid (FFA) content. Therefore, this study, an electrochemical approach for determination FFA has been explored as alternative replace conventional method (titration method). was developed based on electrochemically reduced graphene oxide (rGO) coupled with gold nan...

New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellu...

Observations on the binding of a variety of chemical carcinogens, or their metabolites, to protein in tumor-sensitive tissues have led to the concept that such binding plays a role in carcinogenesis (2). In the case of certain aromatic amines, such as 2-naphthylamine and 4-aminobiphenyl, which produce bladder cancer, it appears that the metabolites rather than the parent compounds are carcinoge...

The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Myco...