In an effort to determine whether the "growth state" and the "mature state" of a neuron are differentiated by different programs of gene expression, we have compared the rapidly transported (group I) proteins in growing and nongrowing axons in rabbits . We observed two polypeptides (GAP-23 and GAP-43) which were of particular interest because of their apparent association with axon growth . GAP...

Conduction velocities and amplitudes of evoked responses were used in experimental models to compare reinnervation through nerve gaps sutured under tension or bridged with nerve grafts. The best results were obtained when end-to-end suture was done without tension. Regeneration through mildly stretched nerve repairs was equivalent to applying a properly tailored graft. Minimal axonal activity w...

background: two main muscles studied in the hand for evaluation of median nerve injuries are opponens pollicis (op) and abductor pollicis brevis (apb). however, riché-cannieu communicating branch (rccb) may limit the use of these muscles in electrodiagnosis. this condition is confusing in the case of median nerve injuries. this study was conducted to evaluate the prevalence of rccb.   methods: ...

End-to-end neurorrhaphy remains the gold standard for transected nerve repair. However, the current dogma is that to be successful, nerve repairs must be tension free. Therefore, nerve gaps are most commonly repaired with grafts. While there is evidence that nerves can regenerate successfully after initial approximation under a tensile force, the amount of tension that deters regeneration of hu...

conclusions our results support the use of pns in some patients with refractory chronic headaches. appropriate surgical planning and technique are important to achieve good clinical outcome and to minimize complications. background subcutaneous peripheral nerve stimulation (pns) has emerged as a useful tool in the treatment of intractable headaches. however, complications such as skin erosion, ...

background: two main muscles studied in the hand for evaluation of median nerve injuries are opponens pollicis (op) and abductor pollicis brevis (apb). however, riché-cannieu communicating branch (rccb) may limit the use of these muscles in electrodiagnosis. this condition is confusing in the case of median nerve injuries. this study was conducted to evaluate the prevalence of rccb.   methods: ...

Background and purpose - Many methods of gastrocnemius lengthening have been described, with different surgical challenges, outcomes, and risks to the sural nerve. Our aims were (1) to locate the gastrocnemius muscular-tendinous junction in relation to the mid-length of the fibula (from here on designated the mid-fibula), (2) to compare the dorsiflexion achieved with dorsal recession or ventral...

We have developed a simple and effective animal model to study the distraction neurogenesis utilizing the sciatic nerve-lengthening technique in rats. The model allows macroscopic, physiological, and histological evaluation of the distraction site. Fourteen adult Harlan Sprague Dawley rats (300-350 g) were used in this study. A 10 mm segment of the right sciatic nerve of each animal in the nerv...

Radial neuropathy is frequently associated with fracture of the middle third of the humerus owing to the course of the nerve adjacent to the humeral shaft. The prevalence varies from 2 to 18% of humeral fractures. The therapeutic management is still controversial. Some authors recommend initial surgical exploration, whereas others prefer observation and intervention only if the injured nerve fa...