There has been a continuously increased interest during recent years in the use of topical vehicle systems that can enhance drug penetration through the skin barrier into the skin or the systemic circulation. In particular, transdermal drug delivery (TDD) is an attractive alternative to conventional oral and injectable dosage forms. Since its introduction about twenty years ago, TDD has generat...

Objective: The present study aimed to evaluate of antimigraine activity methanolic extract Abroma augusta L. leaves in laboratory animals. Methods: was evaluated against nitroglycerine (NTG, 10 mg·kg−1, i. p.) and bradykinin (BK, µg, intra-arterial) induced hyperalgesia rats. Rats were divided randomly into six groups: normal, control, standard (sumatriptan, 42 s. c.), (100,200 400 p. o.). In t...