We explored the effect of intravenous infusions of a bisphosphonate, pamidronate, in the management of chronic mechanical spinal pain, a worldwide public health problem in terms of lost workdays, medical treatment costs, and suffering. Bisphosphonates have an anti-nociceptive effect in animals. In humans, intravenous pamidronate relieves numerous painful conditions, including metastatic bone pa...

OBJECTIVE Fine-needle aspiration biopsy (FNAB) is a mandatory procedure in evaluation of thyroid nodules. However, it is sometimes perceived as a painful procedure by the patients. Efficacy of the needle-free injection of local anesthesia for reducing the pain associated with other cutaneous procedures that involve needle insertion was previously reported. In this double-blind, placebo-controll...

BACKGROUND AND PURPOSE The Patient Reported Outcomes Measurement Information System is a newly developed outcomes measure promulgated by the National Institutes of Health. This study compares changes in pain and physical function-related measures of this system with changes on the Numeric Rating Pain Scale, Roland Morris Disability Index, and the European Quality of Life scale 5D questionnaire ...

A cute pain is a common presenting symptom in the pediatric emergency department (ED). This adverse stimulus occurs as a result of injury and illness. If a child’s pain is not treated quickly and effectively, it can have long-term physical and psychological sequelae [1–3]. These long-term consequences may include anticipatory anxiety during future procedures, a lowering of the pain threshold an...

STUDY OBJECTIVE We compare a high initial dose of 2 mg intravenous hydromorphone against titration of 1 mg intravenous hydromorphone followed by an optional second dose. METHODS Patients aged 21 to 64 years with severe pain were randomly allocated to 2 mg intravenous hydromorphone in a single bolus or the "1+1" hydromorphone titration protocol. 1+1 Patients received 1 mg intravenous hydromorp...

The etiology of chronic fatigue syndrome (CFS) is unknown and no conventional medicine therapies are available. This report presents a clinical case of a patient suffering from CFS who was cured by traditional Korean medicine. A 33-year-old female patient had to take time off work because of terrible fatigue symptoms that did not respond to conventional treatments. Her disorder was significantl...

background: pain is one of the side effects of episiotomy. the virtual reality (vr) is a non-pharmacological method for pain relief. the purpose of this study was to determine the effect of using video glasses on pain reduction in primiparity women during episiotomy repair. methods: this clinical trial was conducted on 30 primiparous parturient women having labor at omolbanin hospital (mashhad,...