previous studies have reported the efficacy of baclofen in the treatment of gastroesophageal reflux diseases (gerd). the objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained release baclofen (sr baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of gerd. a prospective, double blind, place...

Reported herein is the first enantioselective method for simultaneous separation of chiral pharmaceuticals and pesticides using ultra-high-performance liquid chromatography-tandem mass spectrometry. Separation was achieved a ChiralPak IG-U® column (amylose tris(3-chloro-5-methylphenylcarbamate) stationary phase) ethanol as ‘green’ mobile phase organic modifier. Minimum enantiomer resolutions ra...

laryngopharyngeal reflux (lpr) is a variant of gastroesophageal reflux disease (gerd) in which the stomach contents go up into the pharynx and then down into the larynx. lpr causes a wide spectrum of manifestations mainly related to the upper and the lower respiratory system such as laryngitis, asthma, chronic obstructive pulmonary disease, cough, hoarseness, postnasal drip disease, sinusitis, ...

Background and objective:Gastroesophageal reflux is one of the most common esophageal disordersat all age groups, especially in children, due to the transient slackness of sphincter of the lower esophagus, which results in impairment in the quality of life of the infant.Various studies have shown that proton pump inhibitors have a beneficial effect on the treatment of gastroesophageal reflux di...

OBJECTIVE To conduct a systematic evaluation of the efficacy of lansoprazole and omeprazole for the treatment of Helicobacter pylori-associated duodenal ulcer. METHODS Online databases, including CHKD, VIP, China Info, the National Digital Library of China, Google Scholar, PubMed, Lippincott Williams & Wilkins, and Wiley Online Library were searched for related studies. The quality of the stu...

In the present study, the induction of drug-metabolizing enzymes and transporters was evaluated by analyzing mRNA expression in human hepatocytes after exposure to various compounds. The compounds tested included typical enzyme inducers, rifampicin and omeprazole, and controls. All experiments were performed in the presence of 0.1% DMSO. Analysis was performed by the real-time reverse-transcrip...

We examined the effects of YM020 (3-cyanomethyl-2-methyl-8-[(3-methyl-2-butenyl)oxy]-imidazo[1,2- a]pyridine), a novel H+,K(+)-ATPase inhibitor, on gastric acid secretion and experimental gastroduodenal lesions in rats and dogs. Intraduodenal, subcutaneous and oral YM020 inhibited basal gastric acid secretion in pylorus-ligated rats with ED50 values of 9.1, 9.1 and 9.5 mg/kg, respectively. Oral...

BACKGROUND It is known that the pharmacokinetic profile of proton pump inhibitors (PPIs) after postprandial administration may differ among PPIs. The purpose of this study was to compare the inhibitory effects of gastric acid secretion by PPIs administered after a meal, based on a 24-hour intragastric pH monitoring. METHODS Ten healthy men who provided written informed consent participated in...

BACKGROUND/AIMS There have been few studies on the efficacy of proton pump inhibitors and the doses required to treat dyspeptic symptoms observed in clinical practice. The aim of this study was to compare the efficacy of different doses of omeprazole and different administration methods in Helicobacter pylori-negative, dyspeptic patients. METHODS Patients with chronic upper abdominal symptoms...