Oral cancer is the leading cause of death worldwide and it is the eighth most common cause of cancer death. Cancer cells utilize more glucose and amino acids than their benign counterparts. Diagnosis of disease via the analysis of saliva is potentially valuable, as the collection of fluid is associated with fewer compliance problems than the collection of blood. Hence, the present study was und...

PURPOSE This retrospective study evaluates the efficacy and safety of S-1 chemotherapy for recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy. PATIENTS AND METHODS Thirty-nine patients with recurrent and metastatic nasopharyngeal carcinoma who failed previous platinum-based chemotherapy received oral S-1 chemotherapy (twice daily from day 1...

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance between extracellular matrix deposition and proteolytic degradation as well as...

STATEMENT OF THE PROBLEM The head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. The incidence of these tumors and their primary origins are limited in Iranian patients. PURPOSE Therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most ...

lichenoid reactions represent a family of lesions with different etiologic factors and a common clinical and histologic appearance. lichen planus is included with lichenoid reactions and is a relatively common chronic mucocutaneous disorder. the most important complication of lichenoid reactions is the possibility of malignant transformation. that is why it has been considered a precancerous co...

BACKGROUND COX-2 is involved in tumor angiogenesis and modulation of the production of angiogenetic factors by colorectal carcinoma cells. It has been shown that COX-2 inhibitors have inhibitory activities against various types of tumor, including colorectal carcinoma. In this study, we investigated the tumor vessels of small metastatic liver tumors in rats and the effect of meloxicam, a select...

esophageal cancer is the ninth most common malignancy.the incidence of esophageal cancer varies greatly among regions of the world and occurs at a high frequency in asia and northern iran. we report the case of an 80-year-old man with esophageal squamous cell carcinoma who initially presented with a metastatic scalp lesion. esophagoscopy was performed and a lesion was located in the mid-portion...

Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) is a rare genetic condition characterized by the early development of numerous cutaneous carcinomas (BCCs). Although most BCCs are surgically treated with total resection, some lesions may proceed to locally advanced or metastatic stage. Systemic treatment hedgehog inhibitors (HHIs) such as Vismodegib Sonidegib indicated in this popu...

Abstract Megestrol acetate is one of the pharmacological agents used for cancer-associated fatigue. To date, there are no studies on its use in treatment post-COVID-19 (coronavirus disease 2019) So, we report a case metastatic carcinoma lung with partial response three cycles palliative chemotherapy. He was contracted mild COVID-19 infection post his Post this episode, fatigue main and most tro...