Citrullinated synovial antigens and the antibodies produced against them play a important role in the path physiology of RA[1]. Anti-CCP antibody positivity seems to be associated with increased synovial fluid oxidant activity (increased MDA and MPO levels) in patients with RA[2]. Excessive free radical production rather than impaired antioxidant enzymes activity due to autoantibody inhibition ...

Cigarette smoking produces oxidant-mediated changes in the lung important to the pathogenesis of emphysema. Since vitamin E can neutralize reactive oxygen species and prevent peroxidation of unsaturated lipids, it may constitute an important component of the lung's defense against oxidant injury. To better characterize the antioxidant protective role of vitamin E, young asymptomatic smokers and...

Objective: This study was carried out to investigate the effects of curcumin and resveratrol antioxidant enzymes in β-amyloid (Aβ)-induced vitro Alzheimer's Disease (AD) cell model. Methods: In three groups were created; The control group consisted U87 lines, Aβ which AH model formed including β-amyloid-induced U-87 Aβ+ Curcumin+ Resveratrol by adding group. Cell viability evaluated with 3-(4,5...

Aerobic life is connected with continuous production of free radicals, particularly reactive oxygen species (ROS). Cells posses an enzymatic and non-enzymatic antioxidant system to maintain redox homeostasis. Oxidant-antioxidant imbalance resulting in excessive accumulation of ROS is defined as oxidative stress. Oral lichen planus (OLP) is a chronic inflammation of unknown etiology. Several res...

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oxidant-responsive transcription factor known to induce detoxifying and antioxidant genes. Cigarette smoke, with its large oxidant content, is a major stress on the cells of small airway epithelium, which are vulnerable to oxidant damage. We assessed the role of cigarette smoke in activation of Nrf2 in the human small airway epithelium in...

It is well appreciated that reactive oxygen species (ROS) are deleterious to mammals, including humans, especially when generated in abnormally large quantities from cellular metabolism. Whereas the mechanisms leading to the production of ROS are rather well delineated, the mechanisms underlying tissue susceptibility or tolerance to oxidant stress remain elusive. Through an experimental selecti...

AIM Oxidative stress is considered one of the main events that lead to aging and neurodegeneration. Antioxidant treatments used to counteract oxidative damage have been associated with a wide variety of side effects or at the utmost to be ineffective. The aim of the present study was to investigate the antioxidant property of a natural mineral, the tribomechanically micronized zeolite (MZ). M...

objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...

Evidences that higher natural antioxidant (NA) intake provides protection against cardiovascular disease (CVD) are contradictory. Oxidative-induced endothelial cells (ECs) injury is the key step in the onset and progression of CVD and for this reason the cellular responses resulting from NA interaction with ECs are actively investigated. This study was designed to investigate the direct impact ...