Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002. Combination therapy is now explored in clinical trials as a new treatment approach for VL to reduce the length of treatment and potentially prevent selection of re...

background: ferrous sulfate is the most used supplement for treating anemia, but it can result in unfavorable side effects. nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. this study investigates the effects of nanoparticles containing iron on blood and inflammatory markers in comparison to ferrous sulfate in anemic rat...

The bacterial ribosome is the primary target for many classes of antibiotics including the aminoglycosides, tetracyclins, macrolides, and oxazolidinones, all of which interact predominantly with ribosomal RNA (rRNA), thereby interfering with cellular protein synthesis. 2] These antibiotics bind selectively to RNA sites that harbor unique sequence signatures that distinguish bacterial from eukar...

The aim of the present study was to evaluate and compare efficiacy albendazole paromomycine treatments against natural Giardia spp. infection in calves. calves were divided two groups six animals each with similar parasitic loads Giardiaspp. cysts. Albendazole (20 mg/kg) paromomycin (50 administrated orally group A P, respectively, for three consecutive days. efficiacies drugs evaluated by anal...

Visceral leishmaniasis (VL) is a vector-borne parasitic disease targeting tissue macrophages. It is among the most neglected infectious diseases. Classical manifestations of VL include chronic fever, hepatosplenomegaly, and pancytopenia. Most cases can be detected through serologic and molecular testing. Although therapy has historically relied on antimonials, newer therapeutic options include ...

Today, due to the natural decline of oil exploitation, the use of methods of oil recovery, has made significant progress. However, these methods are accompanied by accumulation and deposition of mineral deposits in oil field installations. In the present study, aqueous solutions, strontium sulfate, barium sulfate, manganese sulfate and nickel sulfate are studied, in terms of EUNIQUAC model and ...

Background: This study aimed to evaluate the therapeutic efficacy of paromomycin sulphate on serum amyloid A (SAA) and haptoglobin (Hp) in Cryptosporidiosis goat kids. Methods: In study, stool samples were taken from kids Cryptosporidium was detected via rapid test kit. Then, by examining same microscopically, we included 9 50 mg/kg administered which spp. for five days as a treatment. For SAA ...

The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q fever, as it enhances the activity of the antibiotic against the causative bacterium Coxiella burnetii residing within macrophage phagolysosomes. As there is a similar cellular host-pathogen biology for Leishmania parasites, this study aimed to determine whether such an approach could also...