In this paper, we use an M/G/C/C state dependent queuing model within a complex network topology to determine the different performance measures for pedestrian traffic flow. The occupants in this network topology need to go through some source corridors, from which they can choose their suitable exiting corridors. The performance measures were calculated using arrival rates that maximize the th...

Channels and cavities play important roles in macromolecular functions, serving as access/exit routes for substrates/products, cofactor and drug binding, catalytic sites, and ligand/protein. In addition, channels formed by transmembrane (TM) proteins serve as transporters and ion channels. MolAxis is a new sensitive and fast tool for the identification and classification of channels and cavitie...

LEOPARD syndrome is an autosomal dominant hereditary disease, which is characterized with cutaneous pigmented patches, electrocardiographic changes, ocular hypertelorism, retarded growth, pulmonic stenosis, genital abnormalities and congenital deafness. The gene of this disease have high penetrance but expression is varied and incomplete forms may be seen. We report a 23 year-old woman wi...

In this paper, a multi-perspective decision support system (MP-DSS)‎ ‎to design hierarchical public transportation network is developed‎. ‎Since this problem depends on different perspectives‎, ‎MP-DSS consists of two sub-systems with macro and micro sub-systems based on travel information‎, ‎land use and expert knowledge‎. ‎In the micro sub-system‎, ‎two sub-modules are developed considering o...

Protected area systems and conservation corridors can help mitigate the impacts of climate change on Amazonian biodiversity. We propose conservation design criteria that will help species survive in situ or adjust range distributions in response to increased drought. The first priority is to protect the western Amazon, identified as the 'Core Amazon', due to stable rainfall regimes and macro-ec...

interrupting the processes which control ecosystem resources has dramatic impacts on the rangeland conditions. to protect ecosystems and landscape, it needs to understand the ecosystem processes which regulate the ecosystem resources. as main components of ecosystems, patches and inter-patches play important roles in energy and materials cascade. ecologically, functional parameters such as stab...

Least-cost models for focal species are widely used to design wildlife corridors. To evaluate the least-cost modeling approach used to develop 15 linkage designs in southern California, USA, we assessed robustness of the largest and least constrained linkage. Species experts parameterized models for eight species with weights for four habitat factors (land cover, topographic position, elevation...

Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge area of hair follicle transplantation plus dermabrasionwith dermabrasion alone in stable genera...