The treatment of pediatric leukemias has been developed through sequential clinical trials designed to improve patient survival and preserve quality of life (Brochstein et al., 1987). A patient's clinical and biological features are predictive of risk of relapse and determine the aggressiveness of the prescribed clinical treatment protocol. Patients determined to be at high risk for recurrence ...

Cataract is clouding of the eye lens that reduces the amount of incoming light and results in deteriorating vision. Blindness is thought to reach 75 million by 2020. Of these, unoperated cataract may be expected to account for at least 35 million. Thus, the burden of cataract is increasing remorselessly. Embelica officinalis is reported to have a very good antioxidant property and thus we hypot...

Clear eye lens is responsible for correct vision. Ageing effect acquires opacity at structure causing foggy or blurred It termed as cataract. This may become cause of permanent blindness if remain unidentified and untreated. Due to hazards change in environment adoption sluggish lifestyle many diseases like cataract are becoming universal challenge health organization over the world. Lack medic...

Aim To determine the risk factors for macular edema (ME) in children with uveitis. Methods A retrospective study was conducted of 150 pediatric patients (264 eyes) uveitis attending 2 tertiary medical centers. Data were collected from files on demographics, type uveitis, etiology, clinical findings, treatment, and time to development ME. Risk ME identified. Results developed 63 eyes (23.9%) ove...

PURPOSE Congenital cataracts occur in 3-4 per 10,000 live births and account for 5% to 20% of pediatric blindness worldwide. With more than 37 genes known to be associated with isolated congenital cataract, whole exome sequencing (WES) was recently introduced as an efficient method for screening all known factors. METHODS Whole exome analysis in two members of a four-generation pedigree affec...

Two 8- and 9-year-old brothers were referred to the Pediatric Oncology Unit, Perugia General Hospital, because of hyperferritinemia. Both had a history of bilateral cataract and epilepsy. Genetic investigation revealed two distinct mutations in iron haemostasis genes; homozygosity for the HFE gene H63D mutation in the younger and heterozygosity in the elder. Both displayed heterozygosity for C3...

Cordia obliqua has a long history of use in the treatment cataract and other eye-related problems Indian traditional medicine. High oxidative stress is one major underlying causes which results precipitation natural protein present lenses with aging. This research been carried out to determine anti-cataract activity by performing various antioxidant techniques such as 1,1-diphenyl-2-picrylhydra...