نتایج جستجو برای: pentylenetetrazol
تعداد نتایج: 544 فیلتر نتایج به سال:
Neuroactive steroids represent potential antiepileptic drugs. We tested a newly synthesized analogue of allopregnanolone 3alpha-hydroxy-21xi,22-oxido-21-homo-5alpha-pregnan-20-on (HOHP) against two types of pentylenetetrazol-induced seizures (100 mg/kg s.c.) in 12- and 25-day-old rats. Ganaxolone, a neuroactive steroid in clinical trials, served as a reference drug. Pretreatment with either ste...
Objective(s): Stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. Epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. We investigated the potential seizure response of the rat offspring to prenatal stress; the stres...
NO concentrations in the frontal cortex of anaesthetised rat were measured by using an electrochemical sensor, before and after intraperitoneal (i.p.) administration of a hypnotic drug, pentobarbital (20-40 mg/kg) or a convulsant agent, pentylenetetrazol (50 mg/kg). The results show that NO concentrations were decreased by pentobarbital, while pentylenetetrazole increased the NO levels. These d...
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