Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male...

To improve drug selectivity toward target cells, one interesting approach for drug delivery is to use polymer nanoparticles. A two-layered ONIOM Becke3- LYP: UFF calculation was carried out to study the structural and thermodynamic properties of the interaction between acetamide derivatives and the PCA-PEG-PCA copolymers. The Interaction enthalpies and the Gibbs free energies between acetamide ...

Anti N-methyl-D-aspartate receptor (NMDR) encephalitis has been recognized as the most frequent autoimmune encephalitis in children after acute demyelinating encephalomyelitis (ADEM).However due to the variable the variable clinical presentation, the paucity of specific finding on standard laboratory and radiological investigation remains under recognized. First discribed in 2005, most commonly...

Mutually inhibitory pacemaker neurons with duty cycle close to 50% operate as a half-center oscillator (anti-phase coordination, i.e., 180 degrees out of phase), even in the presence of weak to modest gap junctional coupling. For electrical coupling strength above a critical value synchronization occurs. But, as shown here with modeling studies, the effects of electrical coupling depend critica...

background selenium deficiency is a common problem in patients with chronic kidney disease (ckd). this micronutrient has anti-inflammatory and anti-oxidant effects. selenium is also found in high concentrations in the thyroid gland. objectives to determine the effect of selenium supplementation on thyroid function tests and acute phase reactants in hemodialysis patients. patients and methods in...

Titanium dioxide (TiO2)nanoparticles have been frequently employed in the environmental treatment and purification purposes as a cheap and highly efficient photocatalyst. A photocatalyst can facilitate the breakdown and removal of a variety of environmental pollutants at room temperature. TiO2 photocatalyst is the best candidatebecause of its strong oxidized ability, non-toxicity and longtherma...

Dendrostellera lessertii (Thymelaeaceae) is a toxic plant that grows in parts of Iran. The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines. Methods: In a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...

gabapentin (gbp) is one of the new antiepileptic drugs (aeds) applied extensively in neurology and psychiatry. the advantage of new aeds includes newer mechanism of action, broad spectrum of anti-seizure effects, lesser drug interactions and fewer side effects. gbp is a cyclized analogue of gaba but it does not interact with gaba receptors, nor does it inhibit gaba uptake or prevent the degener...

aim : the aim of this study was to determine the prevalence of celiac disease in iranian patients suffering from chronic depression or schizophrenia. background : psychiatric disorders are common in untreated celiac disease. patients and methods : two hundred iranian inpatient men with in chronic phase of depressive disorders or schizophrenia, and 200 age-matched healthy male subjects were scre...