OBJECTIVE To compare the cost effectiveness of sildenafil and papaverine-phentolamine injections for treating erectile dysfunction. DESIGN Cost utility analysis comparing treatment with sildenafil (allowing a switch to injection therapy) and treatment with papaverine-phentolamine (no switch allowed). Costs and effects were estimated from the societal perspective. Using time trade-off, a sampl...

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

CURRENT OPINION Traditional concern regarding the use of epinephrine in the fingers is based on 21 reported cases of digital necrosis after being injected with a local anesthetic with epinephrine. Most occurred before 1950 and all used procaine, which may have been expired and thus may have had a toxically low pH. The effects of epinephine can be easily and expediently reversed with the use f p...

We examined in conscious dogs the effects of /9-adrenergic receptor blockade on measurements of left circumflex coronary arterial diameter and blood flow and calculations of late diastolic coronary resistance and left circumflex coronary internal cross-sectional area. Propranolol (combined /3iand 02-adrenergjc receptor blockade) and atenolol (selective /Stadrenergic receptor blockade) elicited ...

Delayed postischemic brain hypoperfusion and hypermetabolism are likely detrimental factors to neurologic recovery after transient global brain ischemia and may be mediated by catecholamines acting via adrenergic receptors. We evaluated the effects of alpha and beta receptor blockade on cerebral blood flow (CBF) and metabolism after 16 min transient global brain ischemia. Ischemia was induced b...

THE recognition of the importance of the sympathetic nervous system in the control of the systemic arterial blood pressure has stimulated the search for therapeutically useful sympathoadrenergic blocking agents that may be of use in the diagnosis and treatment of hypertensive vascular disease. Numerous agents of diverse chemical structure have been developed and explored for such therapeutic ef...