A sequence S is potentiallyKp1,p2,...,pt graphical if it has a realization containing aKp1,p2,...,pt as a subgraph, whereKp1,p2,...,pt is a complete t-partite graph with partition sizes p1, p2, ..., pt(p1 ≥ p2 ≥ ... ≥ pt ≥ 1). Let σ(Kp1,p2,...,pt, n) denote the smallest degree sum such that every n-term graphical sequence S with σ(S) ≥ σ(Kp1,p2,...,pt, n) is potentially Kp1,p2,...,pt graphical....

Insulin receptor substrate (IRS)-2 is structurally and functionally similar to IRS-1. Indeed, stimulation with insulin or insulin-like growth factor I led to the rapid tyrosine phosphorylation of both IRS-1 and IRS-2, which in turn activated phosphatidylinositol (PI) 3-kinase in L6 cells and rat skeletal muscle. However, IRS-2 was rapidly dephosphorylated (3-10 min after the addition of insulin...

The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an important role in controlling growth and metabolism. We report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)) regulates the cell type-specific activation and localization of mTORC1. PI(3)P formation depends on the class II phosphatidylinos...

Membrane lipids have been implicated in many critical cellular processes, yet little is known about the role of asymmetric lipid distribution in cell morphogenesis. The phosphoinositide bis-phosphate PI(4,5)P(2) is essential for polarized growth in a range of organisms. Although an asymmetric distribution of this phospholipid has been observed in some cells, long-range gradients of PI(4,5)P(2) ...

Interleukin-2 (IL-2) prevents cell apoptosis and promotes survival, but the involved mechanisms have not been completely defined. Although phosphatidylinositide 3-kinase (PI 3-kinase) has been implicated in IL-2-mediated survival mechanisms, none of the 3 chains of the IL-2 receptor (IL-2R) expresses a binding site for PI 3-kinase. However, IL-2Rbeta does express a Syk-binding motif. By using a...

The problem under investigation contains a computational simulation of a specific heat exchanger with complex geometry fins. The problem solved is potentially interesting for researchers and engineers working on solar collectors and aerospace industry. It is known that heat transfer enhancement can be achieved by creating longitudinal vortices in the flow. These vortices can be generated by arc...

We report the first evidence for $X(3872)$ production in two-photon interactions by tagging either electron or position final state, exploring highly virtual photon region. The search is performed $e^+e^- \rightarrow e^+e^-J/\psi\pi^+\pi^-$, using 825 fb$^{-1}$ of data collected Belle detector operated at KEKB $e^+e^-$ collider. observe three candidates with an expected background $0.11\pm 0.10...

The principal aim of this paper is to employ Bessel-type operators in proving the inequality $$\displaystyle \begin{aligned} \int _0^\pi dx \, |f'(x)|{ }^2 \geq \dfrac {1}{4}\int {|f(x)|{ }^2}{\sin ^2 (x)}+\dfrac |f(x)|{ }^2,\quad f\in H_0^1 ((0,\pi )), \end{aligned} $$ where both constants 1?4 appearing above are optimal. In addition, strict sense that equality holds if and only f ? 0. ...

In this work, we systematically study the OZI-allowed two-body strong decay properties of $1P$- and $1D$-wave $\Sigma_c$ baryons within $j $-$j$ coupling scheme in framework quark pair creation model. For a comparison, also give predictions chiral Some model dependencies can be found two models. The calculations indicate that: (i) $1P$-wave $\lambda$-mode states most likely to relatively narrow...