To study the resistance to standard dosage of clopidogrel among Iranian patients following percutaneous coronary intervention measured by platelet aggregation test.Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who were under treatment with aspirin, but had no history of clopidogrel usage, entered the study. Patients received standard dosage...

To study the resistance to standard dosage of clopidogrel among Iranian patients following percutaneous coronary intervention measured by platelet aggregation test.Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who were under treatment with aspirin, but had no history of clopidogrel usage, entered the study. Patients received standard dosage...

Background: Cell therapy and cell culture have received much attention in recent decades. Suitable cell growth requires growth supplements such as fetal bovine serum (FBS). FBS is component rich in nutrients, growth factors and supplementary compounds. However, FBS utilization has some limitations including mass production. Therefore, finding alternatives with the same growth promoting effects ...

Background: Recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. We aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. Methods: In vitro susceptibility to samples of 10 random human platelet concentrates was determin...

background: mesenchymal stromal cells (mscs) are employed in various different clinical settings in order to modulate immune response. human autologous and allogeneic supplements including platelet derivatives such as platelet lysate (pl), platelet-released factors (prf) and serum are assessed in clinical studies to replace fetal bovine serum (fbs). the immunosuppressive activity and multi-pote...

Background: Infant jaundice is one the most common causes of hospitalization in infant in the first month of birth, which is defined an abnormal increase in blood bilirubin levels. Exchange transfusion is the recommended treatment for neonatal jaundice who do not respond to phototherapy and experience dangerous complication of jaundice and signs of kernicterus. However, this treatment may lead ...

introduction: the aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (nlr), platelet-to-lymphocyte ratio (plr), and mean platelet volume (mpv) in patients with recurrent aphthous stomatitis (ras).   materials and methods: eighty patients who were diagnosed with ras between january 2014 and january 2016 were included in this study. eighty age- and gender-matched healthy subject...

background: the present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (bmsc). methods: the bmsc were isolated from female sprague-dawley rats and evaluated for different markers, such as fibronectin, cd106, cd90, oct-4 and cd45. transdifferentiation of olc from bmsc was obtained by exposing the bmsc to dmso and 1 µm all-trans-retinoic a...

platelet activating factor (paf) is a novel signaling phospholipids that in addition to platelet activation has many biological properties. the acrosome reaction, as an essential step in mammalian fertilization, can occur in response to several agents such as paf. therefore, the present study aimed to assess the effect of paf on the motility and acrosome reaction of ram spermatozoa. semen was c...

platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of cerastes persicus fieldi and echis carinatus were investigated. the partial fractionation was performed on a sephadex g-100 column. two fractions separated from cerastes persicus fieldi showed anti platelet aggregation activity on adp (200 µm)-induced platelet aggregation (ca 80% inhibi...