Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle. They block caffeine-induced rigor and the attendant increase in Ca(45) influx and efflux. Increased net uptake of sodium, loss of potassium, and concurrent increase in oxygen consumption are all effectively blocked by procaine. Evidence is presented that the inhibitory effect of the local an...

The majority of immediate type adverse reactions to local anaesthetics seem to be non-IgE-mediated. We report a case of a 31-year-old woman, who developed conjunctivitis and conjunctival erythema immediately after intrauterine application of a local anaesthetic. Skin prick testing and intradermal testing were done with lidocaine, mepivacaine, and procaine. Intradermal testing showed positive re...

Using a pharmacological probe, procaine hydrochloride, the authors elicited consistent and selective activation of anterior limbic and paralimbic structures in normal human volunteers as documented by H215O positron emission tomography. This activation was associated with a range of emotional, somatic, and visceral experiences, often similar to those experienced during the aura of temporal lobe...

The immediate relief of lightning pains in tabetics remains a problem. Though sedatives are still the commonest drugs prescribed, medical measures such as administration of vitamin B1, ephedrine, adrenaline, and insulin have been suggested on supposed etiological grounds, but have failed to meet with general approval. Surgical procedures, such as epidural injections, division of the nerve roots...

A simple, accurate and sensitive method for the microdetermination of benzocaine, lignocaine and procaine hydrochlorides in pure forms and in pharmaceutical formulations is described. The procedure is based on the reaction of those drugs in an aqueous acidic medium with p-benzoquinone to form charge-transfer complexes. The method has been used for the determination of 5.0-70, 5.0-60 and 5.0-90 ...

The cytocidal action of Naja naja kaouthia venom on rabbit red blood cells and S-180 tumor cells treated with local anesthetics (tetracaine, lidocaine and procaine) were studied. The S-180 cells were more sensitive to the venom than the red blood cells which required albumin for efficient hemolysis in the 10 minute assay. All three local anesthetics at lower concentrations protected both cell t...