The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of proteasome activity blocks proplatelet formation in human and mouse megakaryocytes. We also found that m...

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In the discussion in Chapter 2, we assumed that we had only data on marketlevel prices and quantities, together with cost and demand shifters. In this case, we were forced to make inferences about costs from the market outcomes together with an equilibrium assumption on the model. We saw how the equilibrium assumption can influence the resulting estimates of cost. Inside of learning about costs...

Importance sampling methods of wavelet products can deal with some direct rendering applications with only two functions. For multiple functions sampling that are more useful in global rendering, we present a wavelet-based factor method to simplify multiple function integral into triple function product issues. Then an optimal wavelet product representation is introduced. Major algorithms with ...

The aim of this paper is to use the concept of the metafrontier function to study the determination of efficiency differentials and Technological Gap Ratio (TGR) on wheat production in Khorasan Razavi province. In this study, we used the metafrontier function and group frontier based on the concept of Stochastic Nonparametric Envelopment of Data analysis (StoNED). The data used in this stud...

This paper introduces a new data set for the analysis of productivity in U.S. manufacturing. It consists of data on production and input levels when the plants in an industry operate at capacity. The estimates are consistent with those obtained using data on actual operations from the ASM. As an application, I use this data to estimate the rate of growth of technological change that is embodied...

A simulation model was developed to estimate the effect of deficit irrigation upon crop yield. The model was designed to provide relative yield estimates for numerous combinations of irrigation system, crop growth and irrigation management parameters. A daily soil moisture balance was used to predict evaporation and transpiration from which crop yields were estimated. Gross irrigation water req...

There is a paucity of literature concerning the relation between the resource utilization decisions of the salaried hospital based physician and patient outcomes in a national health service. The purpose of our study is to model and test hospital production where the major decision makers are physicians. We view the outcome process of the hospital as a change in the distribution function over f...